Association between Dental Scores and Saliva Uremic Toxins.
chronic kidney disease
dental health
saliva
uremic toxins
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
received:
15
08
2023
revised:
14
11
2023
accepted:
17
11
2023
medline:
27
11
2023
pubmed:
24
11
2023
entrez:
24
11
2023
Statut:
epublish
Résumé
Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins in the saliva. A total of 88 patients were included in the study, with chronic kidney disease stage 2 to 5 (without kidney replacement). We analysed the total concentrations of eight uremic toxins (trimethylamine N-oxide -TMAO-, Indoxyl Sulfate, P-cresyl-sulfate, Indole 3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid -CMPF-, Kynurenine, Hippuric acid and Phenylacetylglutamine) and three precursors of uremic toxins (Tyrosine, Phenylalanine and Tryptophan) in the saliva using LC-MS/MS. We observed, for the first time, the association between various dental scores: DMFT, FST, CPITN, and OHIS, and saliva uremic toxins and precursors: TMAO, indoxyl sulfate, or hippuric acid. Further prospective interventional studies are required to confirm our results.
Identifiants
pubmed: 37999529
pii: toxins15110666
doi: 10.3390/toxins15110666
pmc: PMC10674306
pii:
doi:
Substances chimiques
hippuric acid
TE0865N2ET
trimethyloxamine
FLD0K1SJ1A
Uremic Toxins
0
Indican
N187WK1Y1J
Toxins, Biological
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CHU de Bordeaux
ID : CHUBX 2013/11
Références
Int J Mol Sci. 2023 Jul 14;24(14):
pubmed: 37511232
Iran J Kidney Dis. 2022 May;16(3):203-208
pubmed: 35714215
J Am Dent Assoc. 1964 Jan;68:7-13
pubmed: 14076341
J Cell Physiol. 2020 Jan;235(1):599-610
pubmed: 31271661
J Bras Nefrol. 2014 Jul-Sep;36(3):289-96
pubmed: 25317610
Annu Rev Nutr. 2017 Aug 21;37:157-181
pubmed: 28715991
Toxins (Basel). 2023 Feb 13;15(2):
pubmed: 36828466
Sci Rep. 2023 Jul 21;13(1):11805
pubmed: 37479734
Toxins (Basel). 2021 Feb 13;13(2):
pubmed: 33668632
Acta Odontol Scand. 2022 Jul;80(5):338-345
pubmed: 34875210
Int Dent J. 1982 Sep;32(3):281-91
pubmed: 6958657
Toxins (Basel). 2021 Mar 31;13(4):
pubmed: 33807343
Am J Kidney Dis. 2000 Dec;36(6):1110-4
pubmed: 11096033
Community Dent Health. 1987 Dec;4(4):407-14
pubmed: 3480772
Int J Environ Res Public Health. 2023 Jan 11;20(2):
pubmed: 36674052
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Sep;88(3):316-9
pubmed: 10503861
Circ Res. 2015 Jan 30;116(3):448-55
pubmed: 25599331
Clin Chem Lab Med. 2018 Dec 19;57(2):230-237
pubmed: 30052514
Biomed Res Int. 2015;2015:370314
pubmed: 25922833
J Pain Res. 2017 Aug 24;10:2031-2040
pubmed: 28894386
Nephrol Dial Transplant. 2016 Oct;31(10):1647-53
pubmed: 27035674
Pharmaceuticals (Basel). 2023 Mar 28;16(4):
pubmed: 37111261