Cardiovascular autonomic nervous function in children conceived by assisted reproductive technology with frozen or fresh embryo transfer.

Assisted reproduction Cardiovascular autonomic nervous function Children Fresh embryo transfer Frozen embryo transfer

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
24 Nov 2023
Historique:
medline: 24 11 2023
pubmed: 24 11 2023
entrez: 24 11 2023
Statut: aheadofprint

Résumé

As a result of epigenetic changes, children conceived by assisted reproduction may be at risk of premature cardiovascular ageing with notably increased blood pressures. Their cardiovascular autonomic nervous function is unknown. Therefore, this study investigated the cardiovascular autonomic nervous function in 8-12-year-old children (51% girls) conceived naturally (n=33) or by assisted reproduction with frozen (n=34) or fresh (n=38) embryo transfer by evaluating heart rate variability; during rest; from provocation maneuvers; and from baroreflex function. Heart rate and blood pressure response to provocation maneuvers and baroreflex function were comparable between children conceived naturally or by assisted reproduction. The mean RR-interval and high-frequency component of heart rate variability were lower in children conceived by assisted reproduction than in children conceived naturally. Children conceived by fresh embryo transfer had

Identifiants

DOI: 10.1152/ajpheart.00680.2023 PMID: 37999646
pubmed: 37999646
doi: 10.1152/ajpheart.00680.2023
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Novo Nordisk Fonden (NNF)
ID : NNF19OC0054340
Organisme : Novo Nordisk Fonden (NNF)
ID : NNF18OC0034092
Organisme : The Research Foundation at Rigshospitalet

Auteurs

Ikram Mizrak (I)

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital; Fertility Department, Rigshospitalet, Copenhagen University Hospital, Herlev Hospital, Herlev, Herlev, Denmark.

Morten A V Lund (MAV)

Department of Cardiology, University Hospital Copenhagen - Rigshospitalet, Copenhagen, Copenhagen, Denmark.

Ann V Landgrebe (AV)

Department of Biomedical Sciences, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Denmark.

Louise L Asserhøj (LL)

Fertility Department, Rigshospitalet, Copenhagen University Hospital; Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital; International Center for Research & Train, Copenhagen, Copenhagen, Denmark.

Niels-Henrik Holstein-Rathlou (NH)

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Gorm Greisen (G)

Department of Neonatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Tine D Clausen (TD)

Department of Obstetrics, Rigshospitalet, Department of Gynecology and Obstetrics, North Zealand Hospital, Copenhagen University Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Katharina M Main (KM)

Growth and Reproduction, Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital; International Center for Research & Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaR, Copenhagen, Copenhagen, Denmark.

Niels G Vejlstrup (NG)

Department of Cardiology, University Hospital Copenhagen - Rigshospitalet, Copenhagen, Denmark.

Rikke B Jensen (RB)

Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital; International Center for Research & Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), Rigshospitalet, Copenhagen University Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Copenhagen, Denmark.

Anja Pinborg (A)

Fertility Department, Rigshospitalet, Copenhagen University Hospital; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Copenhagen, Denmark.

Per L Madsen (PL)

Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital; Department of Clinical Medicine, University of Copenhagen, Herlev, Herlev, Denmark.

Classifications MeSH