Screening of the activity of sixty essential oils against plasmodium early mosquito stages in vitro and machine learning analysis reveals new putative inhibitors of malaria parasites.
Essential oils
Machine learning
Malaria
Ookinete
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
26
04
2023
revised:
20
10
2023
accepted:
08
11
2023
pubmed:
24
11
2023
medline:
24
11
2023
entrez:
24
11
2023
Statut:
ppublish
Résumé
Malaria, an infectious disease with a tremendous impact on human health is caused by Plasmodium parasites, and transmitted by Anopheles mosquitoes. New approaches to control the disease involve transmission blocking strategies aiming to target the parasite in the mosquito. Here, we investigated the putative inhibitory activity of essential oils and their components on the early mosquito stages of the parasite. We employed an in vitro assay of gametocyte-to-ookinete development of the rodent model parasite Plasmodium berghei combined with high content screening. 60 essential oils with known composition were tested. The results revealed that fifteen EOs had inhibitory activity. Furthermore, a machine learning approach was used to identify the putative inhibitory components. Five of the most important chemical components indicated by the machine learning-based models were actually confirmed by the experimental approach. This combined approach was used for the first time to identify the potential transmission blocking activity of essential oils and single components at the zygote and ookinete stages.
Identifiants
pubmed: 38000094
pii: S2211-3207(23)00035-0
doi: 10.1016/j.ijpddr.2023.11.002
pmc: PMC10709126
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-93Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.
Références
Sci Rep. 2020 Feb 14;10(1):2653
pubmed: 32060344
Front Neuroinform. 2014 Feb 21;8:14
pubmed: 24600388
Nature. 1998 Mar 19;392(6673):289-92
pubmed: 9521324
Nature. 2017 Oct 26;550(7677):515-518
pubmed: 29019978
Biochim Biophys Acta Gen Subj. 2021 Mar;1865(3):129813
pubmed: 33321150
Antimicrob Agents Chemother. 2001 Sep;45(9):2553-8
pubmed: 11502528
Pathogens. 2021 Aug 03;10(8):
pubmed: 34451443
Bioinformatics. 2000 May;16(5):412-24
pubmed: 10871264
Molecules. 2019 Mar 03;24(5):
pubmed: 30832446
Nat Rev Dis Primers. 2017 Aug 03;3:17050
pubmed: 28770814
Biomed Res Int. 2018 Oct 2;2018:6860271
pubmed: 30386794
Microorganisms. 2022 Apr 24;10(5):
pubmed: 35630332
Southeast Asian J Trop Med Public Health. 2012 Mar;43(2):270-9
pubmed: 23082579
Biomed Pharmacother. 2020 Oct;130:110624
pubmed: 33503761
Parasit Vectors. 2017 Sep 6;10(1):411
pubmed: 28874207
Parasitol Today. 1995 Apr;11(4):138-43
pubmed: 15275357
Cell Microbiol. 2004 Jul;6(7):671-85
pubmed: 15186403
Molecules. 2017 Jan 26;22(2):
pubmed: 28134788
Iran J Pharm Res. 2018 Winter;17(1):268-275
pubmed: 29755558
J Physiol Anthropol. 2021 Jan 7;40(1):1
pubmed: 33413683
J Parasitol. 1974 Oct;60(5):819-24
pubmed: 4610107
Int J Mol Sci. 2020 Dec 04;21(23):
pubmed: 33291608
Nature. 2015 Feb 5;518(7537):125-6
pubmed: 25653001
Front Microbiol. 2022 Apr 25;13:840893
pubmed: 35547120
Antimicrob Agents Chemother. 2006 May;50(5):1731-7
pubmed: 16641443
Planta Med. 2005 Jan;71(1):20-3
pubmed: 15678368
Pharmaceuticals (Basel). 2010 Jul 21;3(7):2322-2332
pubmed: 27713355
Malar J. 2012 Jul 02;11:219
pubmed: 22747579
Molecules. 2020 May 25;25(10):
pubmed: 32466318
Front Microbiol. 2020 Mar 17;11:269
pubmed: 32256458