A Decade of Efforts to Add Value to Child Health Research Practices.

To identify practices that add value to improve the design, conduct, and reporting of child health research and reduce research waste. In order to categorize the contributions of members of Standards for Research (StaR) in Child Health network , we developed a novel Child Health Improving Research Practices (CHIRP) framework comprised of five domains meant to counteract avoidable child health research waste and improve quality: 1) address research questions relevant to children, their families, clinicians, and researchers; 2) apply appropriate research design, conduct and analysis; 3) ensure efficient research oversight and regulation; 4) Provide accessible research protocols and reports; and 5) develop unbiased and usable research reports, including 17 responsible research practice recommendations. All child health research relevant publications by the 48 original StaR standards' authors over the last decade were identified, and main topic areas were categorized using this framework. A total of 247 publications were included in the final sample: 100 publications (41%) in domain 1 (three recommendations), 77 publications (31%) in domain 2 (three), 35 publications (14%) in domain 3 (four), 20 publications (8%) in domain 4 (four), and 15 publications (6%) in domain 5 (three). We identified readily implementable "responsible" research practices to counter child health research waste and improve quality, especially in the areas of patient and families' engagement throughout the research process, developing Core Outcome Sets, and addressing ethics and regulatory oversight issues. While most of the practices are readily implementable, increased awareness of methodological issues and wider guideline uptake is needed to improve child health research. The CHIRP Framework can be used to guide responsible research practices that add value to child health research.

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.