Occlusive membranes for guided regeneration of inflamed tissue defects.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
received:
04
06
2023
accepted:
08
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
24
11
2023
Statut:
epublish
Résumé
Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.
Identifiants
pubmed: 38001080
doi: 10.1038/s41467-023-43428-3
pii: 10.1038/s41467-023-43428-3
pmc: PMC10673922
doi:
Substances chimiques
Membranes, Artificial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7687Subventions
Organisme : Ministry of National Defense, Republic of Korea | Defense Acquisition Program Administration (DAPA)
ID : KRIT-CT-21-034
Organisme : National Research Foundation of Korea (NRF)
ID : NRF-2022K2A9A1A0609182711
Organisme : Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs)
ID : HI22C1609
Informations de copyright
© 2023. The Author(s).
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