Impacts of perinatal dioxin exposure on gaze behavior in 2-year-old children in the largest dioxin-contaminated area in Vietnam.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
received:
19
06
2023
accepted:
20
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
24
11
2023
Statut:
epublish
Résumé
Fifty-five children aged 2 years from a birth cohort in the largest dioxin-contaminated area in Bien Hoa city, Vietnam participated in this survey to examine gaze behavior. Exposure levels were indicated by 2,3,7,8-tetrachlorodibenzo-p-dibenzodioxin (TCDD) and toxic equivalent of polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (TEQ-PCDD/Fs) levels in maternal breast milk. The percentage of the total fixation duration on the face (% Face), mouth (% Mouth), and eye areas (% Eyes) when viewing silent and conversation scenes was used as gaze behavior indices. When they reached 3-year-old, autistic behavior was assessed using the Autism Spectrum Rating Scale (ASRS). A general linear model adjusted for confounding factors was used to compare gaze indices and ASRS scores between high and low dioxin exposure groups. Effects of perinatal dioxin exposure on gaze behavior were found only when viewing conversation scenes indicated by lower % Face for boys in high TCDD exposure group and lower % Eyes for girls in high TEQ-PCDD/Fs group. Increased autistic traits showed by higher ASRS scores at 3-year-old were found in both gender in the high TCDD exposure group. These findings indicate that perinatal TCDD and TEQ-PCDD/Fs exposure may reduce gaze behavior in 2-year-old children, predicting increased autistic traits at 3-year-old.
Identifiants
pubmed: 38001134
doi: 10.1038/s41598-023-47893-0
pii: 10.1038/s41598-023-47893-0
pmc: PMC10673870
doi:
Substances chimiques
Polychlorinated Dibenzodioxins
0
dibenzodioxin
0
Dioxins
0
Dibenzofurans
0
Polychlorinated Biphenyls
DFC2HB4I0K
Environmental Pollutants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20679Subventions
Organisme : the Japan Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research
ID : 2530502
Organisme : the Japan Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research
ID : 17H04665
Informations de copyright
© 2023. The Author(s).
Références
PLoS One. 2016 Jan 29;11(1):e0147655
pubmed: 26824471
Front Psychol. 2014 May 08;5:397
pubmed: 24847297
Curr Opin Pediatr. 2008 Apr;20(2):184-90
pubmed: 18332716
PLoS One. 2013;8(3):e59196
pubmed: 23555630
Philos Trans R Soc Lond B Biol Sci. 2016 Jan 19;371(1686):20150081
pubmed: 26644599
Sci Total Environ. 2019 Aug 15;678:217-226
pubmed: 31075589
Int J Hyg Environ Health. 2020 Jan;223(1):132-141
pubmed: 31588017
J Child Psychol Psychiatry. 2018 Aug;59(8):872-880
pubmed: 29359802
J Pediatr. 2016 Aug;175:159-166.e2
pubmed: 27189679
Environ Sci Technol. 2015 May 5;49(9):5732-42
pubmed: 25798921
Environ Res. 2017 Nov;159:222-231
pubmed: 28803151
Environ Health Perspect. 2002 Oct;110(10):A593-8
pubmed: 12361940
Sci Total Environ. 2015 Dec 1;536:575-581
pubmed: 26247686
Sci Total Environ. 2018 Feb 15;615:1312-1318
pubmed: 29751436
Toxics. 2022 Apr 24;10(5):
pubmed: 35622626
J Child Psychol Psychiatry. 2012 Aug;53(8):903-13
pubmed: 22428993
Sci Rep. 2017 Jun 28;7(1):4315
pubmed: 28659613
J Am Acad Child Adolesc Psychiatry. 2018 Aug;57(8):561-570
pubmed: 30071977
Toxics. 2022 Mar 22;10(4):
pubmed: 35448411
Front Psychol. 2018 Aug 03;9:1355
pubmed: 30123162
PLoS One. 2011;6(5):e19858
pubmed: 21625638
J Vis. 2012 Dec 03;12(13):
pubmed: 23211270
Toxicol Sci. 2006 Oct;93(2):223-41
pubmed: 16829543
Mol Psychiatry. 2014 Nov;19(11):1220-6
pubmed: 24637425
Sci Total Environ. 2020 Dec 20;749:141083
pubmed: 32829268
Ann Neurol. 2007 Aug;62(2):128-36
pubmed: 17487877
Child Dev. 2015 Mar-Apr;86(2):362-78
pubmed: 25403424
Eur J Paediatr Neurol. 2017 Mar;21(2):272-279
pubmed: 27889381
Occup Environ Med. 2013 Sep;70(9):656-62
pubmed: 23390198
Environ Int. 2012 Jan;38(1):79-86
pubmed: 21982037
Sci Total Environ. 2019 Jun 1;667:718-729
pubmed: 30849612
Clin Neurophysiol. 2008 Jul;119(7):1486-95
pubmed: 18450506
Pediatrics. 2012 Jun;129(6):e1453-60
pubmed: 22641752
Int J Hyg Environ Health. 2021 Mar;232:113661
pubmed: 33296778