Context-specific functions of chromatin remodellers in development and disease.


Journal

Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779

Informations de publication

Date de publication:
May 2024
Historique:
accepted: 27 09 2023
pubmed: 25 11 2023
medline: 25 11 2023
entrez: 24 11 2023
Statut: ppublish

Résumé

Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human genetic studies demonstrate remarkable biological specificity and dosage sensitivity of the thirty-two adenosine triphosphate (ATP)-dependent chromatin remodellers encoded in the human genome. Mutations in remodellers produce many human developmental disorders and cancers, motivating efforts to investigate their distinct functions in biologically relevant settings. Exquisitely specific biological functions seem to be an emergent property in mammals, and in many cases are based on the combinatorial assembly of subunits and the generation of stable, composite surfaces. Critical interactions between remodelling complex subunits, the nucleosome and other transcriptional regulators are now being defined from structural and biochemical studies. In addition, in vivo analyses of remodellers at relevant genetic loci have provided minute-by-minute insights into their dynamics. These studies are proposing new models for the determinants of remodeller localization and function on chromatin.

Identifiants

pubmed: 38001317
doi: 10.1038/s41576-023-00666-x
pii: 10.1038/s41576-023-00666-x
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

340-361

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Sai Gourisankar (S)

Department of Pathology, Stanford University, Stanford, CA, USA.
Department of Chemical Engineering, Stanford University, Stanford, CA, USA.

Andrey Krokhotin (A)

Department of Pathology, Stanford University, Stanford, CA, USA.
Department of Developmental Biology, Stanford University, Stanford, CA, USA.

Wendy Wenderski (W)

Department of Pathology, Stanford University, Stanford, CA, USA.
Department of Developmental Biology, Stanford University, Stanford, CA, USA.

Gerald R Crabtree (GR)

Department of Pathology, Stanford University, Stanford, CA, USA. crabtree@stanford.edu.
Department of Developmental Biology, Stanford University, Stanford, CA, USA. crabtree@stanford.edu.

Classifications MeSH