Multiparametric Ultrasound for Diagnosing Testicular Lesions: Everything You Need to Know in Daily Clinical Practice.
color-Doppler ultrasound (CDUS)
contrast-enhanced ultrasound (CEUS)
differential diagnosis
gray-scale ultrasound (GSUS)
multi-parametric ultrasound (mp-US)
sonoelastography (SE)
testicular lesions
testicular tumors
ultrasound (US)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Nov 2023
08 Nov 2023
Historique:
received:
29
08
2023
revised:
20
10
2023
accepted:
24
10
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Ultrasonography (US) represents the gold standard imaging method for the assessment of testicular lesions (TL). The gray-scale (GSUS) and color-Doppler (CDUS) ultrasound examination allow sonographers to investigate the size, margins, echotexture, and vascular features of TLs with the aim to differentiate benign from malignant lesions. Recently, the use of contrast-enhanced US (CEUS) and sonoelastography (SE) has led to further improvements in the differential diagnosis of TL. Although GSUS and CDUS are often sufficient to suggest the benign or malignant nature of the TL, CEUS can be decisive in the differential diagnosis of unclear findings, while SE can help to strengthen the diagnosis. The contemporary combination of GSUS, CDUS, CEUS, and SE has led to a new diagnostic paradigm named multiparametric US (mp-US), which is able to provide a more detailed characterization of TLs than single techniques alone. This narrative and pictorial review aimed to describe the mp-US appearance of several TLs. An extensive Medline search was performed to identify studies in the English language focusing on the mp-US evaluation of TLs. A practical mp-US "identity card" and iconographic characterization of several benign and malignant TLs is provided herein. The mp-US characterization of TL reported herein can be useful in daily clinical practice.
Sections du résumé
BACKGROUND
BACKGROUND
Ultrasonography (US) represents the gold standard imaging method for the assessment of testicular lesions (TL). The gray-scale (GSUS) and color-Doppler (CDUS) ultrasound examination allow sonographers to investigate the size, margins, echotexture, and vascular features of TLs with the aim to differentiate benign from malignant lesions. Recently, the use of contrast-enhanced US (CEUS) and sonoelastography (SE) has led to further improvements in the differential diagnosis of TL. Although GSUS and CDUS are often sufficient to suggest the benign or malignant nature of the TL, CEUS can be decisive in the differential diagnosis of unclear findings, while SE can help to strengthen the diagnosis. The contemporary combination of GSUS, CDUS, CEUS, and SE has led to a new diagnostic paradigm named multiparametric US (mp-US), which is able to provide a more detailed characterization of TLs than single techniques alone. This narrative and pictorial review aimed to describe the mp-US appearance of several TLs.
METHODS
METHODS
An extensive Medline search was performed to identify studies in the English language focusing on the mp-US evaluation of TLs.
RESULTS
RESULTS
A practical mp-US "identity card" and iconographic characterization of several benign and malignant TLs is provided herein.
CONCLUSIONS
CONCLUSIONS
The mp-US characterization of TL reported herein can be useful in daily clinical practice.
Identifiants
pubmed: 38001591
pii: cancers15225332
doi: 10.3390/cancers15225332
pmc: PMC10670367
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Int J Clin Oncol. 2011 Jun;16(3):203-9
pubmed: 21069550
Clin Radiol. 2010 Jun;65(6):496-7
pubmed: 20451019
J Clin Endocrinol Metab. 2004 Aug;89(8):4078-88
pubmed: 15292351
BMJ Case Rep. 2021 Mar 2;14(3):
pubmed: 33653833
Andrology. 2016 Nov;4(6):1193-1203
pubmed: 27565451
Can Urol Assoc J. 2013 Sep-Oct;7(9-10):E614-7
pubmed: 24069109
Andrology. 2022 Oct;10 Suppl 2:118-132
pubmed: 35930758
Clin Hemorheol Microcirc. 2019;73(2):347-357
pubmed: 31156146
Radiographics. 2017 Jul-Aug;37(4):1085-1098
pubmed: 28574809
J Clin Imaging Sci. 2019 Jun 14;9:27
pubmed: 31448178
Eur Radiol. 2012 Apr;22(4):721-30
pubmed: 22028111
J Postgrad Med. 2005 Apr-Jun;51(2):109-11, discussion 111
pubmed: 16006701
Hum Reprod Update. 2015 Jan-Feb;21(1):56-83
pubmed: 25038770
Transl Androl Urol. 2021 Feb;10(2):562-573
pubmed: 33718059
J Urol. 2003 Nov;170(5):1783-6
pubmed: 14532776
Clin Radiol. 2018 Mar;73(3):322.e1-322.e9
pubmed: 29122221
Hum Reprod Update. 2006 May-Jun;12(3):303-23
pubmed: 16540528
J Ultrasound. 2013 Sep 04;16(4):171-8
pubmed: 24432171
Eur Radiol. 2021 Jul;31(7):4918-4928
pubmed: 33449189
Am J Surg Pathol. 1998 Nov;22(11):1361-7
pubmed: 9808128
Ultrasonography. 2022 Apr;41(2):325-334
pubmed: 34674454
Ann Oncol. 2018 Aug 1;29(8):1658-1686
pubmed: 30113631
Eur J Med Res. 2022 May 12;27(1):67
pubmed: 35550623
Cancer. 2000 Jun 1;88(11):2636-41
pubmed: 10861443
Am J Clin Pathol. 1949 Aug;19(8):725-49
pubmed: 18135500
Br J Radiol. 2012 Nov;85 Spec No 1:S41-53
pubmed: 22674702
J Ultrasound Med. 2017 Apr;36(4):821-831
pubmed: 27914180
Ultrasound. 2016 Feb;24(1):23-33
pubmed: 27433272
Urol Ann. 2015 Oct-Dec;7(4):530-3
pubmed: 26692682
Cancer. 2021 Sep 1;127(17):3067-3081
pubmed: 34031876
World J Urol. 1995;13(4):230-2
pubmed: 8528297
Diagn Interv Radiol. 2011 Mar;17(1):52-63
pubmed: 20677130
J Ultrasound. 2014 May 31;17(3):233-8
pubmed: 25177399
J Ultrasound Med. 2003 May;22(5):515-21
pubmed: 12751863
Am J Surg Pathol. 1998 Jun;22(6):709-21
pubmed: 9630178
Clin Radiol. 2007 Apr;62(4):289-302
pubmed: 17331822
Eur Urol. 2023 Sep;84(3):289-301
pubmed: 37183161
J Ultrasound Med. 2018 Dec;37(12):2949-2953
pubmed: 29665033
Andrology. 2022 Sep;10(6):1150-1171
pubmed: 35735741
Urology. 2014 Jan;83(1):195-7
pubmed: 24080220
Hum Reprod. 2019 Aug 1;34(8):1389-1403
pubmed: 31532522
Transl Androl Urol. 2020 Oct;9(5):2393-2399
pubmed: 33209712
Lancet. 2016 Apr 23;387(10029):1762-74
pubmed: 26651223
J Clin Oncol. 2017 Apr 1;35(10):1036-1040
pubmed: 27992270
BJU Int. 2004 Jul;94(1):74-8
pubmed: 15217435
J Urol. 2002 Mar;167(3):1299-302
pubmed: 11832717
Eur Radiol. 2016 Jul;26(7):2268-78
pubmed: 26497666
Int J Androl. 2009 Oct;32(5):524-31
pubmed: 18498357
Eur Urol. 1994;26(1):56-60
pubmed: 7925531
J Endocrinol Invest. 2021 Mar;44(3):391-402
pubmed: 32691371
Crit Rev Oncol Hematol. 2008 Feb;65(2):183-9
pubmed: 17962036
Eur Urol. 2019 Nov;76(5):615-623
pubmed: 31324498
Eur Radiol. 2015 Feb;25(2):323-30
pubmed: 25316054
N Engl J Med. 2007 May 3;356(18):1835-41
pubmed: 17476009
J Ultrasound Med. 2015 Jul;34(7):1319-28
pubmed: 26112637
BMJ Case Rep. 2017 Jul 31;2017:
pubmed: 28765489
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620938947
pubmed: 32618206
Radiographics. 2002 Jan-Feb;22(1):189-216
pubmed: 11796908
J Pathol. 2003 Mar;199(3):378-86
pubmed: 12579540
Int Braz J Urol. 2022 Nov-Dec;48(6):981-987
pubmed: 36037260
Ultraschall Med. 2016 Apr;37(2):201-5
pubmed: 25607628
J Urol. 1996 Jul;156(1):85-8
pubmed: 8648846
Can Urol Assoc J. 2014 Mar-Apr;8(3-4):E181-3
pubmed: 24678361
J Ultrasound Med. 2012 Jan;31(1):115-22
pubmed: 22215776
Ultrasound Med Biol. 2020 Nov;46(11):2956-2964
pubmed: 32863063
Front Endocrinol (Lausanne). 2019 Mar 21;10:164
pubmed: 30949131
Radiology. 2017 Nov;285(2):640-649
pubmed: 28628420
Case Rep Oncol. 2017 Apr 27;10(1):388-391
pubmed: 28559825
Andrology. 2021 Sep;9(5):1331-1355
pubmed: 34089245
Cancer Imaging. 2013 Feb 24;13:26-35
pubmed: 23439108
Ultrasonography. 2019 Oct;38(4):302-310
pubmed: 31430839
Endocr Rev. 2019 Aug 1;40(4):973-987
pubmed: 30882882
Andrology. 2019 Nov;7(6):778-793
pubmed: 31099174
J Pediatr Urol. 2013 Dec;9(6 Pt B):1032-7
pubmed: 23507289
Actas Urol Esp. 2008 Apr;32(4):461-3
pubmed: 18540271
Int J Cancer. 2022 Sep 1;151(5):692-698
pubmed: 35277970
Cancer. 1978 Jan;41(1):369-76
pubmed: 564234
Ultraschall Med. 2014 Dec;35(6):534-9
pubmed: 25140496
BMC Endocr Disord. 2014 Oct 11;14:84
pubmed: 25306429
Radiology. 1987 May;163(2):537-8
pubmed: 3550884
J Ultrasound Med. 2010 May;29(5):831-7
pubmed: 20427796
Medicine (Baltimore). 2018 Sep;97(37):e12390
pubmed: 30213007
Ultraschall Med. 2019 Aug;40(4):425-453
pubmed: 31238377
Br J Radiol. 2007 Aug;80(956):e184-7
pubmed: 17762053
Virchows Arch. 1997 Apr;430(4):301-9
pubmed: 9134041
Eur J Radiol. 2013 Nov;82(11):1904-12
pubmed: 23816164
Cancers (Basel). 2022 Jun 29;14(13):
pubmed: 35804952
BJU Int. 2011 Nov;108(10):1603-7
pubmed: 21631694
J Ultrasound Med. 2004 Jul;23(7):959-64
pubmed: 15292565
Int J Surg Case Rep. 2015;12:102-5
pubmed: 26048630
Radiology. 2012 May;263(2):584-9
pubmed: 22396607
Front Med (Lausanne). 2021 Jan 27;7:610384
pubmed: 33585510
Radiographics. 2001 Oct;21 Spec No:S273-81
pubmed: 11598263
BJU Int. 2006 Nov;98(5):1005-7; discussion 1007
pubmed: 17034602
BMC Urol. 2022 Dec 22;22(1):210
pubmed: 36550425
Asian J Androl. 2019 Mar-Apr;21(2):196-200
pubmed: 30648671
J Urol. 1998 Jun;159(6):1954-7
pubmed: 9598496
Asian J Androl. 2023 Jan-Feb;25(1):50-57
pubmed: 35708357
J Urol. 2018 Aug;200(2):353-360
pubmed: 29530784
BMC Urol. 2019 Jun 11;19(1):52
pubmed: 31185974
AJR Am J Roentgenol. 2011 Apr;196(4):834-41
pubmed: 21427332
BJU Int. 2004 Apr;93(6):888
pubmed: 15050017
Ultraschall Med. 2015 Aug;36(4):315-7
pubmed: 26241118
AJR Am J Roentgenol. 2005 May;184(5):1587-93
pubmed: 15855121
Clin Nucl Med. 2020 Jan;45(1):85-86
pubmed: 31693625
Eur Radiol. 2001;11(2):220-8
pubmed: 11218018
Ultrasound Med Biol. 2016 Aug;42(8):1807-15
pubmed: 27181687
Cancer. 1981 Feb 1;47(3):577-82
pubmed: 7226006
Urol Int. 2012;89(2):196-202
pubmed: 22677786
Fertil Steril. 2016 Feb;105(2):322-8.e1
pubmed: 26604070
Eur Urol. 2022 Nov;82(5):458-468
pubmed: 35853783
Andrology. 2021 Sep;9(5):1369-1382
pubmed: 34043256
Medicina (Kaunas). 2023 Apr 07;59(4):
pubmed: 37109682
Eur Radiol. 2011 Sep;21(9):1831-40
pubmed: 21633826
Histopathology. 2017 Feb;70(3):335-346
pubmed: 27747907
J Clin Oncol. 2010 Jul 10;28(20):3388-404
pubmed: 20530278
Abdom Radiol (NY). 2020 Jul;45(7):2063-2081
pubmed: 31748822
Radiology. 1988 Jul;168(1):19-23
pubmed: 3289090
Radiology. 2003 Apr;227(1):18-36
pubmed: 12616012
Cancers (Basel). 2022 Jul 27;14(15):
pubmed: 35954321
Andrology. 2021 Mar;9(2):559-576
pubmed: 33244893
AJR Am J Roentgenol. 2012 Sep;199(3):W345-54
pubmed: 22915425
Physiol Rev. 2016 Jan;96(1):55-97
pubmed: 26582516
Urology. 2021 Aug;154:16-23
pubmed: 33621585
Pediatr Radiol. 1992;22(2):99-101
pubmed: 1501960
J Surg Oncol. 2018 Sep;118(4):630-635
pubmed: 30196556
Urology. 2006 Oct;68(4):890.e7-8
pubmed: 17070383
Andrology. 2021 Sep;9(5):1356-1368
pubmed: 34114745
Radiology. 2014 Nov;273(2):606-18
pubmed: 24968192
Urol Case Rep. 2017 Nov 22;16:101-103
pubmed: 29204364
Nat Rev Urol. 2013 Dec;10(12):703-12
pubmed: 24217678
BMJ Case Rep. 2018 Jun 4;2018:
pubmed: 29866662
Crit Rev Oncol Hematol. 2021 Sep;165:103452
pubmed: 34384861
J Ultrasound Med. 2011 Nov;30(11):1604-5
pubmed: 22039036
Radiographics. 2021 Oct;41(6):1698-1716
pubmed: 34597218
J Ultrasound Med. 2017 Feb;36(2):409-420
pubmed: 28032907
Acta Oncol. 2017 Feb;56(2):220-224
pubmed: 28080187
J Pediatr Surg. 2013 Aug;48(8):1773-7
pubmed: 23932621
Ultrasound. 2022 Feb;30(1):80-84
pubmed: 35173782
Ultraschall Med. 2013 Apr;34(2):169-84
pubmed: 23558397
AJR Am J Roentgenol. 1995 Mar;164(3):645-7
pubmed: 7863887
Andrology. 2020 Sep;8(5):1005-1020
pubmed: 32353207
Eur Radiol. 2007 Nov;17(11):2810-8
pubmed: 17611760
Urology. 2011 May;77(5):1049-53
pubmed: 21334049
Ultraschall Med. 2018 Apr;39(2):e2-e44
pubmed: 29510439
Andrologia. 2008 Jun;40(3):152-7
pubmed: 18477201
Urol Int. 2003;71(3):316-8
pubmed: 14512655
Nat Rev Urol. 2010 Nov;7(11):610-7
pubmed: 21068762
Oncologist. 2020 Jul;25(7):585-590
pubmed: 32043680
J Med Ultrason (2001). 2018 Jan;45(1):103-111
pubmed: 28317072
BJU Int. 2018 Apr;121(4):575-582
pubmed: 29032579
J Med Radiat Sci. 2021 Mar;68(1):21-27
pubmed: 32869524
Jpn J Clin Oncol. 2009 Feb;39(2):124-6
pubmed: 19066212
Abdom Radiol (NY). 2018 Apr;43(4):899-917
pubmed: 29460046