ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma.
ARID1A
CD8+ T cells
IFN response
esophageal adenocarcinoma
lipid metabolism
tumor immunity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Nov 2023
12 Nov 2023
Historique:
received:
16
10
2023
revised:
06
11
2023
accepted:
11
11
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
ARID1A, a member of the chromatin remodeling SWI/SNF complex, is frequently lost in many cancer types, including esophageal adenocarcinoma (EAC). Here, we study the impact of ARID1A deficiency on the anti-tumor immune response in EAC. We find that EAC tumors with ARID1A mutations are associated with enhanced tumor-infiltrating CD8
Identifiants
pubmed: 38001638
pii: cancers15225377
doi: 10.3390/cancers15225377
pmc: PMC10670331
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P01 CA233452
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA237022
Pays : United States
Organisme : NCI NIH HHS
ID : CA233452
Pays : United States
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