The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus.
cardiovascular diseases (CVDs)
endothelial dysfunction (ED)
insulin resistance (IR)
non-communicable diseases (NCDs)
perivascular adipose tissue (PVAT)
type 2 diabetes mellitus (T2DM)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
09 Nov 2023
09 Nov 2023
Historique:
received:
25
09
2023
revised:
27
10
2023
accepted:
05
11
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. Although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.
Identifiants
pubmed: 38002006
pii: biomedicines11113006
doi: 10.3390/biomedicines11113006
pmc: PMC10669084
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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