Gut-Kidney-Heart: A Novel Trilogy.
dysbiosis
gut microbiota
gut–kidney–heart axis
immune system
toxins
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
received:
20
10
2023
revised:
12
11
2023
accepted:
13
11
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
The microbiota represents a key factor in determining health and disease. Its role in inflammation and immunological disorders is well known, but it is also involved in several complex conditions, ranging from neurological to psychiatric, from gastrointestinal to cardiovascular diseases. It has recently been hypothesized that the gut microbiota may act as an intermediary in the close interaction between kidneys and the cardiovascular system, leading to the conceptualization of the "gut-kidney-heart" axis. In this narrative review, we will discuss the impact of the gut microbiota on each system while also reviewing the available data regarding the axis itself. We will also describe the role of gut metabolites in this complex interplay, as well as potential therapeutical perspectives.
Identifiants
pubmed: 38002063
pii: biomedicines11113063
doi: 10.3390/biomedicines11113063
pmc: PMC10669427
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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