Natural Polyketides Act as Promising Antifungal Agents.
antifungal
invasive fungal infections
polyketides
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
24 Oct 2023
24 Oct 2023
Historique:
received:
01
10
2023
revised:
16
10
2023
accepted:
22
10
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability. Consequently, there is an urgent imperative to develop novel antifungal medications for clinical application. This comprehensive review provides a summary of the antifungal properties and mechanisms exhibited by natural polyketides, encompassing macrolide polyethers, polyether polyketides, xanthone polyketides, linear polyketides, hybrid polyketide non-ribosomal peptides, and pyridine derivatives. Investigating natural polyketide compounds and their derivatives has demonstrated their remarkable efficacy and promising clinical application as antifungal agents.
Identifiants
pubmed: 38002254
pii: biom13111572
doi: 10.3390/biom13111572
pmc: PMC10669366
pii:
doi:
Substances chimiques
Antifungal Agents
0
Polyketides
0
Macrolides
0
Peptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key Research and Development Program of China
ID : No.2022YFC2303004
Organisme : National Natural Science Foundation of China
ID : 82020108032
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