Antimicrobial and Cytotoxic Activities of Water-Soluble Isoxazole-Linked 1,3,4-Oxadiazole with Delocalized Charge: In Vitro and In Vivo Results.
Galleria mellonella in vivo model
antimicrobial activity
cationic organic compounds
cytotoxicity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
received:
05
10
2023
revised:
30
10
2023
accepted:
04
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
The distinct structure of cationic organic compounds plays a pivotal role in enhancing their water solubility, which in turn influences their bioavailability. A representative of these compounds, which contains a delocalized charge, is 5-amino-2-(5-amino-3-methyl-1,2-oxazol-4-yl)-3-methyl-2,3-dihydro-1,3,4-oxadiazol-2-ylium bromide (ED). The high-water solubility of ED obviates the need for potentially harmful solvents during in vitro testing. The antibacterial and antifungal activities of the ED compound were assessed in vitro using the microtiter plate method and a biocellulose-based biofilm model. Additionally, its cytotoxic effects on wound bed fibroblasts and keratinocytes were examined. The antistaphylococcal activity of ED was also evaluated using an in vivo larvae model of
Identifiants
pubmed: 38003222
pii: ijms242216033
doi: 10.3390/ijms242216033
pmc: PMC10671643
pii:
doi:
Substances chimiques
1,3,4-oxadiazole
20O2F20OUR
Water
059QF0KO0R
Anti-Infective Agents
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wroclaw Medical University
ID : SUBK.D090.23.007, SUBZ.D090.23.027, SUBZ.D230.23.030.
Références
Bioorg Med Chem Lett. 2018 Nov 1;28(20):3320-3323
pubmed: 30219525
Int J Mol Sci. 2023 Jan 05;24(2):
pubmed: 36674518
Int J Mol Sci. 2023 Feb 03;24(3):
pubmed: 36769319
Eur J Med Chem. 2021 Oct 5;221:113511
pubmed: 34000484
Antioxidants (Basel). 2023 Feb 04;12(2):
pubmed: 36829937
Int J Mol Sci. 2022 Sep 30;23(19):
pubmed: 36232864
Molecules. 2018 Sep 18;23(9):
pubmed: 30231567
Genome Announc. 2018 Jan 11;6(2):
pubmed: 29326202
Int J Mol Sci. 2022 Apr 28;23(9):
pubmed: 35563319
Sci Rep. 2016 Dec 09;6:38610
pubmed: 27934958
Pathogens. 2022 Feb 25;11(3):
pubmed: 35335616
Int J Mol Sci. 2016 Dec 11;17(12):
pubmed: 27973441
Chem Sci. 2020 Mar 23;11(16):4106-4118
pubmed: 34122876
Biochim Biophys Acta. 2016 May;1858(5):936-46
pubmed: 26577273
Curr Opin Microbiol. 2016 Oct;33:13-17
pubmed: 27239942
Int J Mol Sci. 2021 Jun 29;22(13):
pubmed: 34209520
Front Chem. 2023 Sep 07;11:1264747
pubmed: 37744062
Antibiotics (Basel). 2022 Dec 22;12(1):
pubmed: 36671218
Front Microbiol. 2023 Apr 17;14:1149418
pubmed: 37138605
BMC Chem. 2020 Dec 7;14(1):70
pubmed: 33372629
Antibiotics (Basel). 2020 Sep 08;9(9):
pubmed: 32911640
Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202209947
pubmed: 36151600
J Nanobiotechnology. 2021 Jan 7;19(1):12
pubmed: 33413448
Beilstein J Nanotechnol. 2015 Dec 15;6:2396-405
pubmed: 26734530
Pharmaceutics. 2019 May 15;11(5):
pubmed: 31096709
Antimicrob Agents Chemother. 2000 Aug;44(8):2086-92
pubmed: 10898680
Chem Biol Drug Des. 2021 Mar;97(3):572-591
pubmed: 32946168
Eur J Med Chem. 2017 Sep 8;137:292-309
pubmed: 28605676
RSC Adv. 2021 Sep 3;11(47):29668-29674
pubmed: 35479548
Int J Mol Sci. 2021 Apr 13;22(8):
pubmed: 33924416
J Microbiol Immunol Infect. 2017 Feb;50(1):55-61
pubmed: 25682237