Epidermal Growth Factor Receptors in Vascular Endothelial Cells Contribute to Functional Hyperemia in the Brain.

Mice Animals Endothelial Cells / metabolism Hyperemia ErbB Receptors / genetics Brain / metabolism EGF Family of Proteins / metabolism Epidermal Growth Factor / metabolism
cerebral small vessel diseases (cSVD) epidermal growth factor receptor (EGFR) functional hyperemia phosphatidylinositol 4,5-bisphosphate (PIP2) vascular endothelial cells

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
14 Nov 2023
Historique:
received: 15 09 2023
revised: 06 11 2023
accepted: 12 11 2023
medline: 27 11 2023
pubmed: 25 11 2023
entrez: 25 11 2023
Statut: epublish

Résumé

Functional hyperemia-activity-dependent increases in local blood perfusion-underlies the on-demand delivery of blood to regions of enhanced neuronal activity, a process that is crucial for brain health. Importantly, functional hyperemia deficits have been linked to multiple dementia risk factors, including aging, chronic hypertension, and cerebral small vessel disease (cSVD). We previously reported crippled functional hyperemia in a mouse model of genetic cSVD that was likely caused by depletion of phosphatidylinositol 4,5-bisphosphate (PIP

Identifiants

DOI: 10.3390/ijms242216284 PMID: 38003472 PMC: PMC10671586
pubmed: 38003472
pii: ijms242216284
doi: 10.3390/ijms242216284
pmc: PMC10671586
pii:
doi:

Substances chimiques

ErbB Receptors EC 2.7.10.1
EGF Family of Proteins 0
Epidermal Growth Factor 62229-50-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL142888
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM135007
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140027
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110656
Pays : United States
Organisme : NIH HHS
ID : RF1-NS-128963
Pays : United States
Organisme : NIH HHS
ID : R01-HL-142888
Pays : United States
Organisme : NIH HHS
ID : R01-NS-110656
Pays : United States
Organisme : NIH HHS
ID : R35-HL-140027
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS128963
Pays : United States
Organisme : NIH HHS
ID : P20-GM-135007
Pays : United States

Commentaires et corrections

Type : UpdateOf

Références

J Clin Invest. 2010 Feb;120(2):433-45
pubmed: 20071773
Lancet Neurol. 2009 Jul;8(7):643-53
pubmed: 19539236
J Clin Invest. 2021 Sep 15;131(18):
pubmed: 34351870
Front Mol Neurosci. 2022 Dec 13;15:1108978
pubmed: 36583082
Nature. 1996 Oct 24;383(6602):707-10
pubmed: 8878478
Elife. 2016 Aug 01;5:
pubmed: 27476853
Sci Rep. 2021 Mar 31;11(1):7269
pubmed: 33790318
Exp Physiol. 2007 Jul;92(4):641-6
pubmed: 17483201
Nat Neurosci. 2021 Sep;24(9):1198-1209
pubmed: 34354283
Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43
pubmed: 15688065
Nat Neurosci. 2007 Nov;10(11):1369-76
pubmed: 17965657
Brain Res. 2016 Jul 1;1642:436-444
pubmed: 27086972
Nature. 2011 Aug 28;477(7365):495-8
pubmed: 21874019
Nature. 2018 Feb 22;554(7693):475-480
pubmed: 29443965
Genesis. 2009 Feb;47(2):85-92
pubmed: 19115345
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3569-E3577
pubmed: 29581272
Eur J Neurol. 2020 Aug;27(8):1588-1595
pubmed: 32348626
Brain Behav. 2017 Feb 22;7(3):e00624
pubmed: 28293466
PLoS One. 2017 Jun 22;12(6):e0179460
pubmed: 28640817
Nature. 1998 Feb 19;391(6669):803-6
pubmed: 9486652
Hypertension. 2023 Jan;80(1):22-34
pubmed: 36129176
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):
pubmed: 33875602
Nat Rev Genet. 2012 Sep;13(9):654-66
pubmed: 22868267
Am J Pathol. 2021 Nov;191(11):1856-1870
pubmed: 33895122
Nat Protoc. 2019 Nov;14(11):3059-3081
pubmed: 31586162
Physiol Rev. 2006 Jul;86(3):1009-31
pubmed: 16816144
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Nat Rev Mol Cell Biol. 2011 Feb;12(2):104-17
pubmed: 21252999
Transl Stroke Res. 2020 Jun;11(3):517-527
pubmed: 31667734
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1750-9
pubmed: 17557914
Lancet. 1997 Nov 22;350(9090):1511-5
pubmed: 9388399
Microcirculation. 2017 Apr;24(3):
pubmed: 27652592
Nature. 2010 May 27;465(7297):483-6
pubmed: 20445537
Hypertension. 2017 Jan;69(1):60-70
pubmed: 27821617
Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1072-1087
pubmed: 31043073
FASEB J. 2006 Sep;20(11):1936-8
pubmed: 16877529
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E796-805
pubmed: 25646445
Curr Opin Nephrol Hypertens. 2014 Mar;23(2):113-21
pubmed: 24401788
Elife. 2021 Oct 29;10:
pubmed: 34711305
PLoS Biol. 2020 Jul 14;18(7):e3000410
pubmed: 32663219
Circ Res. 2004 Jan 9;94(1):68-76
pubmed: 14656925
Science. 1984 Apr 27;224(4647):417-9
pubmed: 6200934
Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:437-456
pubmed: 31425001
Cancer Cell. 2004 Feb;5(2):115-20
pubmed: 14998487
Nat Neurosci. 2017 May;20(5):717-726
pubmed: 28319610
Acta Physiol (Oxf). 2011 Sep;203(1):47-59
pubmed: 21272266
Brain. 2013 Jun;136(Pt 6):1830-45
pubmed: 23649698
Elife. 2021 Feb 26;10:
pubmed: 33635784
Sci Data. 2018 Aug 21;5:180160
pubmed: 30129931

Auteurs

Hannah R Ferris (HR)

Department of Pharmacology, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.

Nathan C Stine (NC)

Department of Pharmacology, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.

David C Hill-Eubanks (DC)

Department of Pharmacology, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.

Mark T Nelson (MT)

Department of Pharmacology, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.
Vermont Center for Cardiovascular and Brain Health, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.
Division of Cardiovascular Sciences, University of Manchester, Manchester M13 9PL, UK.

George C Wellman (GC)

Department of Pharmacology, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.

Masayo Koide (M)

Department of Pharmacology, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.
Vermont Center for Cardiovascular and Brain Health, Larner College of Medicine University of Vermont, Burlington, VT 05405, USA.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Eucaryotes › Animaux › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hyperhémie › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la famille de l'EGF › Epidermal Growth Factor Receptors in Vascular...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la famille de l'EGF › Facteur de croissance épidermique › Epidermal Growth Factor Receptors in Vascular...