Secretome as a Tool to Treat Neurological Conditions: Are We Ready?
central nervous system
conditioned medium
mesenchymal stem cells
preconditioning
secretome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
received:
03
10
2023
revised:
04
11
2023
accepted:
17
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results observed, there has been a growing interest in the use of cell-free therapies in regenerative medicine, such as the use of stem cell secretome. This review provides an in-depth compilation of data regarding the secretome composition, protocols used for its preparation, as well as existing information on the impact of secretome administration on various brain conditions, pointing out gaps and highlighting relevant findings. Moreover, due to the ability of MSCs to respond differently depending on their microenvironment, preconditioning of MSCs has been used to modulate their composition and, consequently, their therapeutic potential. The different strategies used to modulate the MSC secretome were also reviewed. Although secretome administration was effective in improving functional impairments, regeneration, neuroprotection, and reducing inflammation in brain tissue, a high variability in secretome preparation and administration was identified, compromising the transposition of preclinical data to clinical studies. Indeed, there are no reports of the use of secretome in clinical trials. Despite the existing limitations and lack of clinical data, secretome administration is a potential tool for the treatment of various diseases that impact the CNS.
Identifiants
pubmed: 38003733
pii: ijms242216544
doi: 10.3390/ijms242216544
pmc: PMC10671352
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : UIDP/Multi/00709/2019, UIDB/Multi/00709/2019, UIDP/00709/2020, and UIDB/00709/2020
Organisme : Fundação para a Ciência e Tecnologia
ID : 2021.07854.BD
Organisme : European Regional Development Fund
ID : POCI-01-0145-FEDER-022122
Références
Stem Cell Res Ther. 2019 Mar 21;10(1):105
pubmed: 30898154
Am J Sports Med. 2022 Aug;50(10):2740-2752
pubmed: 35867349
Front Pharmacol. 2020 May 13;11:654
pubmed: 32528277
Oncotarget. 2016 Sep 6;7(36):58089-58104
pubmed: 27517324
CNS Neurosci Ther. 2022 Oct;28(10):1519-1531
pubmed: 35695696
Sci Rep. 2017 Jun 23;7(1):4153
pubmed: 28646200
J Neurotrauma. 2021 Jun 15;38(12):1702-1716
pubmed: 33183134
Stem Cells. 2015 Feb;33(2):456-67
pubmed: 25346537
Nat Rev Mol Cell Biol. 2009 Feb;10(2):148-55
pubmed: 19122676
Pharmaceutics. 2021 Oct 27;13(11):
pubmed: 34834217
Immunobiology. 2022 May;227(3):152178
pubmed: 35259691
Regen Ther. 2022 Aug 28;21:282-287
pubmed: 36092501
Mol Neurobiol. 2018 Mar;55(3):2285-2300
pubmed: 28332151
Curr Gene Ther. 2017;17(5):379-390
pubmed: 29366415
Stroke. 2011 Oct;42(10):2932-9
pubmed: 21836090
Brain Res. 2020 Apr 1;1732:146700
pubmed: 32032613
Int J Mol Sci. 2019 Sep 17;20(18):
pubmed: 31533317
Stem Cell Res Ther. 2019 Mar 15;10(1):96
pubmed: 30876457
Stem Cell Res Ther. 2014 Apr 16;5(2):53
pubmed: 24739658
Neurochem Res. 2018 Nov;43(11):2165-2177
pubmed: 30259257
Int J Stem Cells. 2017 May 30;10(1):60-68
pubmed: 28446004
Cells. 2019 Jul 28;8(8):
pubmed: 31357692
Stem Cells Dev. 2013 Oct 1;22(19):2606-18
pubmed: 23676112
Mol Cell Proteomics. 2007 Oct;6(10):1680-9
pubmed: 17565974
Neuropsychiatr Dis Treat. 2020 Jan 23;16:249-262
pubmed: 32158210
Exp Biol Med (Maywood). 2018 Nov;243(15-16):1233-1242
pubmed: 30614256
J Biomed Sci. 2014 Jan 22;21:5
pubmed: 24447306
Stem Cell Rev Rep. 2015 Apr;11(2):288-97
pubmed: 25420577
Brain Sci. 2022 May 11;12(5):
pubmed: 35625017
Biochemistry (Mosc). 2019 Nov;84(11):1375-1389
pubmed: 31760924
Cell Transplant. 2019 Jul;28(7):874-884
pubmed: 31185737
J Circ Biomark. 2015 Jul 17;4:7
pubmed: 28936243
Nano Lett. 2019 Jan 9;19(1):19-28
pubmed: 30517011
Front Bioeng Biotechnol. 2022 Sep 30;10:1025138
pubmed: 36246376
Cell Prolif. 2013 Dec;46(6):608-27
pubmed: 24118248
Clin Sci (Lond). 2013 Feb;124(3):165-76
pubmed: 22876972
Biomed Mater Eng. 2008;18(3):129-36
pubmed: 18725693
Pain. 2019 Jan;160(1):210-223
pubmed: 30188455
Cell Mol Neurobiol. 2012 Mar;32(2):191-200
pubmed: 21822733
Exp Neurol. 2021 Jul;341:113700
pubmed: 33741350
Neurobiol Dis. 2012 Jun;46(3):635-45
pubmed: 22426403
Regen Biomater. 2022 Feb 24;9:rbac014
pubmed: 35480857
Stem Cells Transl Med. 2016 Jun;5(6):754-63
pubmed: 27160705
Regen Biomater. 2022 Jun 27;9:rbac043
pubmed: 35855109
Front Cell Dev Biol. 2021 Mar 19;9:654885
pubmed: 33869217
J Chem Neuroanat. 2020 Jul;106:101792
pubmed: 32353514
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):170-5
pubmed: 26699510
Adv Pharm Bull. 2020 Jun;10(2):315-322
pubmed: 32373502
Immunol Lett. 2012 Sep;147(1-2):47-54
pubmed: 22705267
J Trauma Acute Care Surg. 2020 Aug;89(2):388-396
pubmed: 32218019
Stem Cells. 2017 Jun;35(6):1446-1460
pubmed: 28316123
Headache. 2018 Jan;58(1):88-101
pubmed: 28925503
Cell Physiol Biochem. 2018;47(1):11-25
pubmed: 29763932
Aging Dis. 2021 Aug 1;12(5):1211-1222
pubmed: 34341703
Neurochem Int. 2017 Dec;111:69-81
pubmed: 27539657
Int J Mol Sci. 2018 Jul 11;19(7):
pubmed: 29997321
Neurol Res Int. 2011;2011:564089
pubmed: 21766025
Brain. 2014 Feb;137(Pt 2):503-19
pubmed: 24176979
Front Neurosci. 2019 Jan 24;13:14
pubmed: 30733666
Stem Cells Int. 2018 Jan 30;2018:8179013
pubmed: 29535781
J Cell Physiol. 2019 Feb;234(2):1354-1368
pubmed: 30076722
Cells. 2019 May 16;8(5):
pubmed: 31100966
Neurosci Lett. 2010 Mar 26;472(3):215-9
pubmed: 20153400
Biochim Biophys Acta. 2013 Nov;1834(11):2442-53
pubmed: 23395702
Lancet. 2008 May 10;371(9624):1612-23
pubmed: 18468545
Cell. 2019 Apr 4;177(2):428-445.e18
pubmed: 30951670
Mol Med Rep. 2015 Jul;12(1):20-30
pubmed: 25739039
Ann Transl Med. 2021 Sep;9(17):1362
pubmed: 34733914
Front Pharmacol. 2019 Sep 27;10:1114
pubmed: 31611796
BMC Neurosci. 2018 Apr 12;19(1):20
pubmed: 29649974
Brain Res Bull. 2022 Mar;180:46-58
pubmed: 34979238
IEEE Trans Biomed Eng. 2019 Oct;66(10):2704-2718
pubmed: 30596564
Circ J. 2011;75(9):2260-8
pubmed: 21747191
Stem Cell Res Ther. 2022 Jul 28;13(1):378
pubmed: 35902882
Cell Stem Cell. 2011 Aug 5;9(2):97-102
pubmed: 21816361
Adv Healthc Mater. 2021 Apr;10(7):e2001689
pubmed: 33433956
Sci Rep. 2018 Jan 23;8(1):1419
pubmed: 29362496
Cell Biol Int. 2021 Apr;45(4):775-784
pubmed: 33300254
Cell Death Dis. 2020 Apr 27;11(4):288
pubmed: 32341347
Biomed Pharmacother. 2021 Aug;140:111709
pubmed: 34020250
Int J Biochem Cell Biol. 2018 Jul;100:49-53
pubmed: 29778527
Stem Cell Res Ther. 2017 May 12;8(1):112
pubmed: 28499457
Exp Cell Res. 2018 Oct 1;371(1):269-277
pubmed: 30142325
Stem Cells. 2011 Feb;29(2):251-62
pubmed: 21732483
Cell Prolif. 2012 Aug;45(4):311-9
pubmed: 22571453
Int J Mol Sci. 2019 May 20;20(10):
pubmed: 31137455
Mol Neurobiol. 2019 Oct;56(10):6902-6927
pubmed: 30941733
Biochimie. 2013 Dec;95(12):2271-85
pubmed: 23827856
J Chem Neuroanat. 2018 Dec;94:21-31
pubmed: 30121327
Ann Transl Med. 2021 Jan;9(1):70
pubmed: 33553363
Prog Retin Eye Res. 2008 Jul;27(4):420-33
pubmed: 18501660
Metab Brain Dis. 2014 Mar;29(1):193-205
pubmed: 24458787
Metab Brain Dis. 2020 Dec;35(8):1329-1340
pubmed: 32761493
Behav Brain Res. 2017 Aug 14;332:99-109
pubmed: 28576310
Stem Cells Transl Med. 2015 Oct;4(10):1131-43
pubmed: 26339036
Exp Neurol. 2022 Nov;357:114182
pubmed: 35901975
Geroscience. 2022 Feb;44(1):293-310
pubmed: 34757568
Brain Res. 2015 Oct 22;1624:489-496
pubmed: 26279113
CNS Neurosci Ther. 2019 Apr;25(4):496-508
pubmed: 30294904
Adv Clin Chem. 2020;98:173-231
pubmed: 32564786
Stem Cell Res Ther. 2020 Jan 21;11(1):32
pubmed: 31964413
J Neurosci Res. 2017 Oct;95(10):2059-2070
pubmed: 28186348
Zebrafish. 2020 May 20;:
pubmed: 32434437
Oncotarget. 2017 Jul 11;8(28):45200-45212
pubmed: 28423355
Cells. 2022 Jul 26;11(15):
pubmed: 35892597
Blood. 2007 Aug 15;110(4):1362-9
pubmed: 17483296
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
Toxicol In Vitro. 2010 Jun;24(4):1053-63
pubmed: 20362047
Stem Cells. 2014 Sep;32(9):2430-42
pubmed: 24805247
Aging (Albany NY). 2020 Sep 23;12(18):18274-18296
pubmed: 32966240
Cell Transplant. 2015;24(12):2615-27
pubmed: 25695896
Neurol Res. 2018 Apr;40(4):258-267
pubmed: 29384015
Stem Cells Dev. 2016 Jul 15;25(14):1073-83
pubmed: 27226274
Addict Biol. 2019 Sep;24(5):994-1007
pubmed: 30239077
BMC Med. 2013 Jun 11;11:146
pubmed: 23758701
Stem Cells Dev. 2014 May 1;23(9):978-89
pubmed: 24341685
Stem Cells Int. 2022 Jun 27;2022:8465294
pubmed: 35795773
Behav Brain Res. 2015 Oct 15;293:189-97
pubmed: 26210934
FASEB J. 2019 Feb;33(2):2514-2525
pubmed: 30260707
Exp Neurol. 2016 Jul;281:81-92
pubmed: 27085395
Int J Mol Sci. 2018 Mar 15;19(3):
pubmed: 29543759
J Cell Sci. 2010 May 15;123(Pt 10):1603-11
pubmed: 20445011
Biomedicines. 2022 Sep 02;10(9):
pubmed: 36140268
Neural Regen Res. 2022 Dec;17(12):2717-2724
pubmed: 35662219
Int J Nanomedicine. 2020 Nov 17;15:9011-9023
pubmed: 33235449
J Neurochem. 2020 Apr;153(2):230-251
pubmed: 31465551
Exp Neurol. 2015 Oct;272:78-87
pubmed: 25797577
Theranostics. 2022 Jan 1;12(1):143-166
pubmed: 34987639
Stem Cell Res Ther. 2019 Nov 5;10(1):318
pubmed: 31690344
Stem Cell Res Ther. 2017 Sep 29;8(1):198
pubmed: 28962585
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
Stem Cells Dev. 2012 Aug 10;21(12):2189-203
pubmed: 22188562
J Trauma Acute Care Surg. 2020 Sep;89(3):536-543
pubmed: 32658440
Sci Rep. 2021 May 25;11(1):10896
pubmed: 34035416
Pharmaceutics. 2021 Nov 29;13(12):
pubmed: 34959314
Cell Death Differ. 2021 Jan;28(1):203-218
pubmed: 32704089
Oncotarget. 2016 Nov 15;7(46):74537-74556
pubmed: 27793019
Mol Ther. 2015 May;23(5):812-823
pubmed: 25868399
J Cell Mol Med. 2021 Nov;25(22):10430-10440
pubmed: 34651412
Nanotoxicology. 2010 Mar;4(1):98-105
pubmed: 20795905
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Int J Oncol. 2015 Jul;47(1):244-52
pubmed: 25963929
Life Sci. 2020 Sep 1;256:118002
pubmed: 32585248
Neurorehabil Neural Repair. 2020 Jul;34(7):616-626
pubmed: 32462980
Stem Cells Transl Med. 2020 Sep;9(9):1068-1084
pubmed: 32496649
J Trauma Acute Care Surg. 2012 Nov;73(5):1161-7
pubmed: 22976425
J Psychiatr Res. 2012 Aug;46(8):1081-5
pubmed: 22633396
Mol Neurobiol. 2017 May;54(4):2659-2673
pubmed: 26993303
Cancer Manag Res. 2018 Oct 18;10:4735-4745
pubmed: 30425570
Theranostics. 2021 Jul 13;11(17):8129-8142
pubmed: 34373732
Int J Mol Sci. 2020 Oct 21;21(20):
pubmed: 33096871
Stem Cell Res Ther. 2015 Jul 01;6:127
pubmed: 26129847
Adv Drug Deliv Rev. 2015 Mar;82-83:1-11
pubmed: 25451858
Regen Med. 2019 Jun;14(6):595-611
pubmed: 31115266
PLoS One. 2010 Apr 26;5(4):e10088
pubmed: 20436665
Front Immunol. 2018 Jan 05;8:1908
pubmed: 29379499
Stem Cells Dev. 2020 Feb 15;29(4):222-234
pubmed: 31830866
Brain Behav Immun. 2017 Feb;60:220-232
pubmed: 27847282
Neuromolecular Med. 2019 Dec;21(4):529-539
pubmed: 31077035
Stem Cells. 2009 Feb;27(2):478-88
pubmed: 19023032
Cells. 2019 Aug 08;8(8):
pubmed: 31398924
Stem Cell Res. 2011 May;6(3):206-14
pubmed: 21419744
Stem Cells. 2020 Oct 1;38(10):1241-1253
pubmed: 32526037
FASEB J. 2018 Feb;32(2):654-668
pubmed: 28970251
Biosens Bioelectron. 2017 May 15;91:588-605
pubmed: 28088752
Tissue Eng Part A. 2013 Jan;19(1-2):24-9
pubmed: 22839964
J Clin Invest. 2016 Aug 1;126(8):2805-20
pubmed: 27348586
Theranostics. 2017 Jan 26;7(3):789-804
pubmed: 28255367
J Neurosurg. 2015 Apr;122(4):856-67
pubmed: 25594326
Int J Nanomedicine. 2020 Sep 22;15:6917-6934
pubmed: 33061359
Int J Mol Sci. 2017 Aug 25;18(9):
pubmed: 28841158
Exp Neurol. 2021 Mar;337:113542
pubmed: 33275952
Stem Cells Cloning. 2022 Apr 14;15:1-9
pubmed: 35444427
Stroke. 2022 Jan;53(1):e14-e18
pubmed: 34847707
J Neurochem. 2010 Sep;114(6):1569-80
pubmed: 20028455
Stem Cell Res Ther. 2021 Jan 7;12(1):31
pubmed: 33413646
Cell Biol Int. 2020 Feb;44(2):499-511
pubmed: 31631484
Med Sci Monit. 2020 Mar 09;26:e920855
pubmed: 32150531
J Trauma Acute Care Surg. 2020 Feb;88(2):207-218
pubmed: 31804413
Open Life Sci. 2022 Mar 17;17(1):189-201
pubmed: 35415238
Regen Med. 2010 Jan;5(1):121-43
pubmed: 20017699
Stem Cell Res Ther. 2019 Jul 8;10(1):205
pubmed: 31286996
Exp Neurol. 2022 Jan;347:113895
pubmed: 34653510
Front Immunol. 2018 Dec 04;9:2837
pubmed: 30564236
J Toxicol Sci. 2016 Apr;41(2):255-64
pubmed: 26961610
Cell Physiol Biochem. 2019;52(6):1280-1291
pubmed: 31026391
CNS Neurosci Ther. 2017 Nov;23(11):866-874
pubmed: 28961381
Cells. 2020 Sep 30;9(10):
pubmed: 33008073
J Neuroinflammation. 2022 Feb 7;19(1):35
pubmed: 35130907
Stem Cells Transl Med. 2017 Feb;6(2):634-646
pubmed: 28191785
PLoS One. 2017 Jan 23;12(1):e0170628
pubmed: 28114422
Cell Transplant. 2013;22(6):977-91
pubmed: 23031629
Circulation. 2006 Apr 18;113(15):1832-41
pubmed: 16606790