Nuclear Receptor PPARα as a Therapeutic Target in Diseases Associated with Lipid Metabolism Disorders.
PPARα
cancer
cell senescence
diabetes-related diseases
lipid metabolism
metabolic disorders
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
13 Nov 2023
13 Nov 2023
Historique:
received:
08
10
2023
revised:
04
11
2023
accepted:
10
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Lipid metabolic diseases have substantial morbidity and mortality rates, posing a significant threat to human health. PPARα, a member of the peroxisome proliferator-activated receptors (PPARs), plays a crucial role in lipid metabolism and immune regulation. Recent studies have increasingly recognized the pivotal involvement of PPARα in diverse pathological conditions. This comprehensive review aims to elucidate the multifaceted role of PPARα in metabolic diseases including liver diseases, diabetes-related diseases, age-related diseases, and cancers, shedding light on the underlying molecular mechanisms and some regulatory effects of natural/synthetic ligands of PPARα. By summarizing the latest research findings on PPARα, we aim to provide a foundation for the possible therapeutic exploitation of PPARα in lipid metabolic diseases.
Identifiants
pubmed: 38004166
pii: nu15224772
doi: 10.3390/nu15224772
pmc: PMC10674366
pii:
doi:
Substances chimiques
PPAR alpha
0
Receptors, Cytoplasmic and Nuclear
0
Lipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 32202717, 32002243
Organisme : China Postdoctoral Science Foundation
ID : 2021M702762
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20210812, BK20200932, BK20220582
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