Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function.
VD/VDR pathway
adipogenesis
adipose tissue
inflammatory response
obesity treatment
vitamin D
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
18 Nov 2023
18 Nov 2023
Historique:
received:
19
10
2023
revised:
10
11
2023
accepted:
16
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Adipose tissue encompasses various types, including White Adipose Tissue (WAT), Brown Adipose Tissue (BAT), and beige adipose tissue, each having distinct roles in energy storage and thermogenesis. Vitamin D (VD), a fat-soluble vitamin, maintains a complex interplay with adipose tissue, exerting significant effects through its receptor (VDR) on the normal development and functioning of adipocytes. The VDR and associated metabolic enzymes are widely expressed in the adipocytes of both rodents and humans, and they partake in the regulation of fat metabolism and functionality through various pathways. These encompass adipocyte differentiation, adipogenesis, inflammatory responses, and adipokine synthesis and secretion. This review primarily appraises the role and mechanisms of VD in different adipocyte differentiation, lipid formation, and inflammatory responses, concentrating on the pivotal role of the VD/VDR pathway in adipogenesis. This insight furnishes new perspectives for the development of micronutrient-related intervention strategies in the prevention and treatment of obesity.
Identifiants
pubmed: 38004226
pii: nu15224832
doi: 10.3390/nu15224832
pmc: PMC10675652
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
Vitamins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Shanghai Planning project of Philosophy and Social
ID : 2020ETY003
Organisme : National Key Research and Development Program of China
ID : 2020YFC2007005
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