Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?
bone density protection
chronic kidney disease
obesity paradox
secreted protein acidic and rich in cysteine (SPARC/osteonectin)
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
06 Nov 2023
06 Nov 2023
Historique:
received:
07
09
2023
revised:
08
10
2023
accepted:
31
10
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Obesity is a health condition that represents a risk factor for numerous diseases and complications. However, obesity might also have-to some extent-some "benefits" in certain situations. This includes potential bone protection in patients suffering from chronic kidney disease. In an attempt to explain such a paradox, we highlight secreted protein acidic and rich in cysteine (SPARC) as a hypothetical mediator of this protection. Indeed, SPARC properties provide a logical rationale to describe such bone protection via its overexpression combined with its calcium-binding and collagen-binding properties. We believe that exploring such hypotheses could open new doors to elucidate unknown pathways towards developing a new generation of molecular therapies.
Identifiants
pubmed: 38004312
pii: life13112172
doi: 10.3390/life13112172
pmc: PMC10672555
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Clin Invest. 2023 Oct 2;133(19):
pubmed: 37781916
Biomolecules. 2021 Nov 13;11(11):
pubmed: 34827687
J Bone Joint Surg Am. 2010 Mar;92(3):743-53
pubmed: 20194335
Arch Med Res. 2008 Aug;39(6):607-9
pubmed: 18662593
Metabolism. 2019 Mar;92:82-97
pubmed: 30502373
Physiol Genomics. 2007 Dec 19;32(1):64-73
pubmed: 17878319
Cancer Treat Rev. 2011 Nov;37(7):559-66
pubmed: 21237573
Exp Gerontol. 2010 Nov;45(11):896-903
pubmed: 20813182
Nat Rev Endocrinol. 2010 Apr;6(4):225-35
pubmed: 20195270
J Bras Nefrol. 2017 Mar;39(1):65-69
pubmed: 28355395
J Nephrol. 2017 Oct;30(5):623-627
pubmed: 28573386
Calcif Tissue Int. 2021 Apr;108(4):410-422
pubmed: 33190187
Front Endocrinol (Lausanne). 2023 Apr 21;14:1161521
pubmed: 37152942
Biomedicines. 2023 May 04;11(5):
pubmed: 37239027
Eat Weight Disord. 2021 Feb;26(1):27-35
pubmed: 31865598
JBMR Plus. 2020 Mar 25;4(5):e10353
pubmed: 32490328
Joint Bone Spine. 2012 Dec;79(6):544-9
pubmed: 23177912
Sports Med Open. 2018 Mar 1;4(1):12
pubmed: 29492711
Diabetes Metab J. 2022 Jan;46(1):15-37
pubmed: 34965646
Dev Genes Evol. 2002 Apr;212(3):124-33
pubmed: 11976950
J Nephrol. 2023 May;36(4):969-978
pubmed: 36715822
Obes Facts. 2017;10(3):207-215
pubmed: 28564650
Int J Biochem Cell Biol. 2019 Dec;117:105627
pubmed: 31589923
Genes (Basel). 2022 Jun 04;13(6):
pubmed: 35741776
Curr Oncol Rep. 2016 Sep;18(9):56
pubmed: 27475805
Handb Exp Pharmacol. 2022;274:181-201
pubmed: 34697666
Medicines (Basel). 2023 May 16;10(5):
pubmed: 37233608
Nutrients. 2018 Dec 05;10(12):
pubmed: 30563174
Obes Surg. 2014 Apr;24(4):604-10
pubmed: 24234777
Cytokine. 2020 Mar;127:154996
pubmed: 31955132
Subcell Biochem. 2019;91:453-476
pubmed: 30888662
Int J Mol Sci. 2023 Jul 29;24(15):
pubmed: 37569556
Cells. 2022 Jun 09;11(12):
pubmed: 35741001
Endocrinology. 2003 Jun;144(6):2588-96
pubmed: 12746322
Medicines (Basel). 2021 Oct 08;8(10):
pubmed: 34677486
Mol Biol Rep. 2023 Jul;50(7):6177-6189
pubmed: 37227675
Cytokine. 2020 Sep;133:155179
pubmed: 32619797
Circulation. 2021 May 25;143(21):e984-e1010
pubmed: 33882682
Am J Physiol Cell Physiol. 2021 Mar 1;320(3):C375-C391
pubmed: 33356944
Circ Res. 2020 May 22;126(11):1477-1500
pubmed: 32437302
Diseases. 2023 Feb 13;11(1):
pubmed: 36810547
J Clin Invest. 2000 Apr;105(7):915-23
pubmed: 10749571
Prog Cardiovasc Dis. 2014 Jan-Feb;56(4):415-25
pubmed: 24438733
Anat Rec (Hoboken). 2020 Jun;303(6):1624-1629
pubmed: 30980479
J Clin Neurosci. 2020 Jun;76:261-263
pubmed: 32305276
Clin Nephrol. 2022 Jan;97(1):10-17
pubmed: 34402786
Eat Weight Disord. 2021 Mar;26(2):417-423
pubmed: 32124408
Life (Basel). 2021 Jan 08;11(1):
pubmed: 33435573
Prog Cardiovasc Dis. 2018 Jul - Aug;61(2):151-156
pubmed: 29852198
J Nephrol. 2017 Oct;30(5):635-643
pubmed: 28900872
Clin Biochem. 2018 Sep;59:17-24
pubmed: 30003880
Am J Physiol Endocrinol Metab. 2023 Jan 1;324(1):E24-E41
pubmed: 36383637
Kidney Int Rep. 2017 Mar;2(2):271-281
pubmed: 28439569
Cell. 1981 Oct;26(1 Pt 1):99-105
pubmed: 7034958
Life Sci. 2019 Jul 15;229:277-287
pubmed: 31150687
Semin Dial. 2004 May-Jun;17(3):229-32
pubmed: 15144550
Clin J Am Soc Nephrol. 2007 Sep;2(5):992-8
pubmed: 17702712
Nat Rev Urol. 2021 Sep;18(9):519-542
pubmed: 34158658
Front Mol Biosci. 2023 Jul 28;10:1235428
pubmed: 37577749
Matrix Biol. 2016 May-Jul;52-54:78-87
pubmed: 26851678
Immunity. 2022 Sep 13;55(9):1609-1626.e7
pubmed: 35963236
J Korean Med Sci. 2013 Apr;28(4):569-74
pubmed: 23579165
Front Nutr. 2022 Jun 24;9:925619
pubmed: 35811945
Cardiovasc Res. 2017 Jul 1;113(9):1074-1086
pubmed: 28549096
Med Hypotheses. 2020 Nov;144:110042
pubmed: 32758883
Front Endocrinol (Lausanne). 2022 Jul 14;13:873699
pubmed: 35909571
Front Endocrinol (Lausanne). 2022 Oct 28;13:1012508
pubmed: 36387862
PLoS One. 2018 Feb 8;13(2):e0192714
pubmed: 29420632
Eat Weight Disord. 2018 Jun;23(3):293-302
pubmed: 29637521
J Dent Res. 2007 Apr;86(4):296-305
pubmed: 17384023
Eur J Endocrinol. 2011 Oct;165(4):597-601
pubmed: 21778250
Med Sci Monit. 2020 Jan 30;26:e919159
pubmed: 31996665
Mayo Clin Proc. 2022 Jun;97(6):1194-1208
pubmed: 35662432
J Musculoskelet Neuronal Interact. 2020 Sep 1;20(3):372-381
pubmed: 32877973
Osteoporos Int. 2009 Apr;20(4):665-74
pubmed: 18696173
Osteoporos Int. 2006;17(3):319-36
pubmed: 16341622
Calcif Tissue Int. 2016 Nov;99(5):472-480
pubmed: 27339669
Eur J Sport Sci. 2017 May;17(4):447-452
pubmed: 27996694
Int J Biochem Cell Biol. 2012 Mar;44(3):480-8
pubmed: 22249026
Bone. 2017 Jul;100:87-93
pubmed: 27847254
Vasc Health Risk Manag. 2019 May 01;15:89-100
pubmed: 31118651
Mol Med Rep. 2013 Aug;8(2):579-84
pubmed: 23764959
Biomolecules. 2021 Jul 16;11(7):
pubmed: 34356671
Hormones (Athens). 2018 Jun;17(2):205-217
pubmed: 29858847