Variations in the Relative Abundance of Gut Bacteria Correlate with Lipid Profiles in Healthy Adults.
Akkermansia muciniphila
Massilistercora timonensis
cholesterol
gut microbiome
hyperlipidaemia
metagenome
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
28 Oct 2023
28 Oct 2023
Historique:
received:
07
09
2023
revised:
04
10
2023
accepted:
26
10
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
The gut microbiome is a versatile system regulating numerous aspects of host metabolism. Among other traits, variations in the composition of gut microbial communities are related to blood lipid patterns and hyperlipidaemia, yet inconsistent association patterns exist. This study aims to assess the relationships between the composition of the gut microbiome and variations in lipid profiles among healthy adults. This study used data and samples from 23 adult participants of a previously conducted dietary intervention study. Circulating lipid measurements and whole-metagenome sequences of the gut microbiome were derived from 180 blood and faecal samples collected from eight visits distributed across an 11-week study. Lipid-related variables explained approximately 4.5% of the variation in gut microbiome compositions, with higher effects observed for total cholesterol and high-density lipoproteins. Species from the genera
Identifiants
pubmed: 38004667
pii: microorganisms11112656
doi: 10.3390/microorganisms11112656
pmc: PMC10673050
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Regional Development Fund "On Implementation of Activity 1.1.1.2 "Post-doctoral Research Aid"
ID : "Investigation of interaction of smoked dietary products with gut microbiota" Agreement Nr. 1.1.1.2/VIAA/1/16/128
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