Comparative Antibacterial and Efflux Pump Inhibitory Activity of Isolated Nerolidol, Farnesol, and α-Bisabolol Sesquiterpenes and Their Liposomal Nanoformulations.
Farnesol
/ pharmacology
Staphylococcus aureus
/ metabolism
Methicillin-Resistant Staphylococcus aureus
/ metabolism
Liposomes
Multidrug Resistance-Associated Proteins
Anti-Bacterial Agents
/ pharmacology
Sesquiterpenes
/ pharmacology
Ethidium
/ pharmacology
Microbial Sensitivity Tests
Bacterial Proteins
/ metabolism
Staphylococcus aureus
efflux pump
fluorescence
liposome
nanoformulation
sesquiterpenes
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
23
08
2023
revised:
31
10
2023
accepted:
14
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
The efflux systems are considered important mechanisms of bacterial resistance due to their ability to extrude various antibiotics. Several naturally occurring compounds, such as sesquiterpenes, have demonstrated antibacterial activity and the ability to inhibit efflux pumps in resistant strains. Therefore, the objective of this research was to analyze the antibacterial and inhibitory activity of the efflux systems NorA, Tet(K), MsrA, and MepA by sesquiterpenes nerolidol, farnesol, and α-bisabolol, used either individually or in liposomal nanoformulation, against multi-resistant
Identifiants
pubmed: 38005371
pii: molecules28227649
doi: 10.3390/molecules28227649
pmc: PMC10675182
pii:
doi:
Substances chimiques
nerolidol
QR6IP857S6
Farnesol
4602-84-0
bisabolol
24WE03BX2T
Liposomes
0
Multidrug Resistance-Associated Proteins
0
Anti-Bacterial Agents
0
Sesquiterpenes
0
Ethidium
EN464416SI
Bacterial Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
ID : DCT-0182-00104.02.00/21
Organisme : Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
ID : 04855159/2022
Organisme : King Saud bin Abdulaziz University for Health Sciences
ID : RSPD2023R709
Références
Pharmaceutics. 2018 Dec 13;10(4):
pubmed: 30551617
Phytomedicine. 2022 May;99:154035
pubmed: 35286935
Nat Rev Microbiol. 2015 Jan;13(1):42-51
pubmed: 25435309
J Antimicrob Chemother. 2003 Jan;51(1):13-7
pubmed: 12493782
Exp Parasitol. 2013 Oct;135(2):337-43
pubmed: 23933281
In Vivo. 2010 Sep-Oct;24(5):751-4
pubmed: 20952744
Br J Pharmacol. 2012 May;166(2):587-601
pubmed: 22049973
J Drug Target. 2005 Jan;13(1):19-27
pubmed: 15848951
Bioorg Med Chem Lett. 2017 Sep 15;27(18):4221-4228
pubmed: 28827113
Pharmaceutics. 2023 Sep 28;15(10):
pubmed: 37896161
Antimicrob Agents Chemother. 2003 Feb;47(2):719-26
pubmed: 12543683
Eur J Pharm Sci. 2021 May 1;160:105753
pubmed: 33581258
Adv Drug Deliv Rev. 2020;156:4-22
pubmed: 32593642
Antimicrob Agents Chemother. 2005 May;49(5):1857-64
pubmed: 15855507
NanoImpact. 2022 Jan;25:100384
pubmed: 35559890
Clin Microbiol Rev. 2006 Apr;19(2):382-402
pubmed: 16614254
Nanoscale. 2019 Jul 21;11(27):13098-13107
pubmed: 31268080
Future Microbiol. 2013 Apr;8(4):491-507
pubmed: 23534361
Arch Microbiol. 2021 Sep;203(7):4303-4311
pubmed: 34110480
ACS Infect Dis. 2020 May 8;6(5):896-908
pubmed: 32208673
Chem Rev. 2021 May 12;121(9):5417-5478
pubmed: 33761243
Int J Antimicrob Agents. 2011 Jan;37(1):70-4
pubmed: 21075604
Food Chem. 2018 Jul 30;255:399-404
pubmed: 29571492
Pharmaceutics. 2018 May 18;10(2):
pubmed: 29783687
Cell Biochem Funct. 2021 Dec;39(8):926-944
pubmed: 34498277
Sci Rep. 2023 Oct 21;13(1):18012
pubmed: 37865639
Antimicrob Agents Chemother. 2010 Dec;54(12):5070-3
pubmed: 20855743
Crit Rev Anal Chem. 2022;52(2):392-412
pubmed: 32799645
Anal Bioanal Chem. 2017 Sep;409(24):5779-5787
pubmed: 28762066
mBio. 2016 Jul 05;7(4):
pubmed: 27381291
Front Chem. 2022 Aug 08;10:963004
pubmed: 36003616
Bioorg Med Chem. 2005 Dec 1;13(23):6477-84
pubmed: 16182538
Sci Rep. 2019 Aug 8;9(1):11506
pubmed: 31395908
Antimicrob Agents Chemother. 1998 Jan;42(1):45-52
pubmed: 9449259
Antibiotics (Basel). 2020 Jan 08;9(1):
pubmed: 31936186
Clin Transl Med. 2017 Dec 11;6(1):44
pubmed: 29230567
Antimicrob Agents Chemother. 2007 Sep;51(9):3235-9
pubmed: 17576828
Nanomedicine. 2017 Jul;13(5):1673-1683
pubmed: 28300658
Antimicrob Agents Chemother. 1999 Oct;43(10):2404-8
pubmed: 10508015
Expert Rev Anti Infect Ther. 2012 Jul;10(7):775-90
pubmed: 22943401
Infect Drug Resist. 2019 Jun 14;12:1703-1718
pubmed: 31354319
Antibiotics (Basel). 2020 Aug 04;9(8):
pubmed: 32759771
Nat Rev Microbiol. 2018 Sep;16(9):523-539
pubmed: 30002505
Food Funct. 2017 Sep 20;8(9):3198-3208
pubmed: 28805832
Drugs. 2004;64(2):159-204
pubmed: 14717618
Antibiotics (Basel). 2020 Jan 14;9(1):
pubmed: 31947642
Nanomaterials (Basel). 2022 Jul 05;12(13):
pubmed: 35808152
Lett Appl Microbiol. 2017 Dec;65(6):462-468
pubmed: 28977678
Drug Dev Ind Pharm. 2008 Jun;34(6):602-8
pubmed: 18568910
Colloids Surf B Biointerfaces. 2016 Jun 1;142:400-407
pubmed: 26974361
ACS Omega. 2023 Sep 22;8(39):35442-35451
pubmed: 37810644
J Control Release. 2020 Feb;318:256-263
pubmed: 31846618
Expert Opin Drug Deliv. 2011 May;8(5):565-80
pubmed: 21492058
Cell Mol Life Sci. 1999 Nov 30;56(9-10):771-8
pubmed: 11212337
BMC Microbiol. 2011 Oct 27;11:241
pubmed: 22032541
Antibiotics (Basel). 2022 May 04;11(5):
pubmed: 35625264
Biomater Sci. 2016 Apr;4(4):555-74
pubmed: 26818789