HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
HERV
HIV-1 cure
latency
transcriptional silencing
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
28 Oct 2023
28 Oct 2023
Historique:
received:
30
09
2023
revised:
26
10
2023
accepted:
26
10
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We propose a novel "block-lock-stop" approach, entailing long term durable silencing of viral expression towards an irreversible transcriptionally inactive latent provirus to achieve long term antiretroviral free control of the virus. A graded transformation of remnant HIV-1 in PLWH from persistent into silent to permanently defective proviruses is proposed, emulating and accelerating the natural path that human endogenous retroviruses (HERVs) take over millions of years. This hypothesis was based on research into delineating the mechanisms of HIV-1 latency, lessons from latency reversing agents and advances of Tat inhibitors, as well as expertise in the biology of HERVs. Insights from elite controllers and the availability of advanced genome engineering technologies for the direct excision of remnant virus set the stage for a rapid path to an HIV-1 cure.
Identifiants
pubmed: 38005849
pii: v15112171
doi: 10.3390/v15112171
pmc: PMC10674359
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : P01 AI169606
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI164559
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA052027
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI172060
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI170166
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA260691
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI083139
Pays : United States
Organisme : NIH HHS
ID : K01 OD031900
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK131526
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147777
Pays : United States
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