Features of Tat Protein in HIV-1 Sub-Subtype A6 Variants Circulating in the Moscow Region, Russia.
HIV-1
Moscow Region
Russia
Tat
sub-subtype A6
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
04 Nov 2023
04 Nov 2023
Historique:
received:
27
09
2023
revised:
02
11
2023
accepted:
02
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Tat, the trans-activator of transcription, is a multifunctional HIV-1 protein that can induce chronic inflammation and the development of somatic diseases in HIV-infected patients. Natural polymorphisms in Tat can impact the propagation of the inflammatory signal. Currently, Tat is considered an object for creating new therapeutic agents. Therefore, the identification of Tat protein features in various HIV-1 variants is a relevant task. The purpose of the study was to characterize the genetic variations of Tat-A6 in virus variants circulating in the Moscow Region. The authors analyzed 252 clinical samples from people living with HIV (PLWH) with different stages of HIV infection. Nested PCR for two fragments (
Identifiants
pubmed: 38005889
pii: v15112212
doi: 10.3390/v15112212
pmc: PMC10675479
pii:
doi:
Substances chimiques
Gene Products, tat
0
tat Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Russian Science Foundation
ID : 23-15-00027
Références
Retrovirology. 2013 Jun 08;10:61
pubmed: 23758766
Ter Arkh. 2017;89(11):44-49
pubmed: 29260745
Nucleic Acids Res. 2016 Jul 8;44(W1):W242-5
pubmed: 27095192
mBio. 2019 Feb 5;10(1):
pubmed: 30723126
Viruses. 2020 Apr 08;12(4):
pubmed: 32276443
Front Cell Infect Microbiol. 2020 Feb 25;10:61
pubmed: 32158701
Retrovirology. 2014 Apr 17;11:30
pubmed: 24742347
Ann Neurol. 2008 Mar;63(3):366-76
pubmed: 18074388
Oncotarget. 2017 Apr 18;8(16):27569-27581
pubmed: 28187438
Front Microbiol. 2019 Feb 26;10:320
pubmed: 30863382
J Neurovirol. 2021 Feb;27(1):126-136
pubmed: 33462791
Sci Rep. 2019 Mar 1;9(1):3308
pubmed: 30824746
Nat Commun. 2018 Jun 8;9(1):2251
pubmed: 29884859
J Virol. 2013 May;87(10):5732-45
pubmed: 23487450
Vopr Virusol. 2022 Jan 08;66(6):452-464
pubmed: 35019252
PLoS One. 2014 Jan 23;9(1):e85452
pubmed: 24465566
Nat Methods. 2012 Jul 30;9(8):772
pubmed: 22847109
Front Immunol. 2019 Feb 13;10:233
pubmed: 30815001
Bioinformatics. 2014 Nov 15;30(22):3276-8
pubmed: 25095880
Viruses. 2023 Apr 18;15(4):
pubmed: 37112971
Med Microbiol Immunol. 2019 Apr;208(2):131-169
pubmed: 30834965
Virol J. 2005 Feb 28;2:17
pubmed: 15737233
Nucleic Acids Res. 1988 Feb 11;16(3):1215
pubmed: 3344216
Retrovirology. 2014 Oct 17;11:88
pubmed: 25323821
J Biol Chem. 2013 Mar 15;288(11):7626-7644
pubmed: 23364796
J Virol. 2004 Mar;78(5):2586-90
pubmed: 14963162
AIDS Res Hum Retroviruses. 2012 Sep;28(9):1152-6
pubmed: 22236201
Mol Biol Cell. 2004 May;15(5):2347-60
pubmed: 15020715
Virus Res. 2018 May 2;250:51-64
pubmed: 29654800
Adv Virol. 2012;2012:123605
pubmed: 22899925
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
AIDS Res Hum Retroviruses. 2015 Apr;31(4):456-60
pubmed: 25738513
AIDS. 2007 Jan 11;21(2):215-23
pubmed: 17197813
Vopr Virusol. 2022 Sep 12;67(4):310-321
pubmed: 36097712
J Biol Chem. 1999 Oct 8;274(41):28837-40
pubmed: 10506122