Does the Human Gut Virome Contribute to Host Health or Disease?
enteric mucosal immunity
gut immunity
gut virome–host immune axis
gut virota
human gut virome
immune homeostatic mechanisms
virome–host interaction
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
20
09
2023
revised:
04
11
2023
accepted:
16
11
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
The human gastrointestinal (GI) tract harbors eukaryotic and prokaryotic viruses and their genomes, metabolites, and proteins, collectively known as the "gut virome". This complex community of viruses colonizing the enteric mucosa is pivotal in regulating host immunity. The mechanisms involved in cross communication between mucosal immunity and the gut virome, as well as their relationship in health and disease, remain largely unknown. Herein, we review the literature on the human gut virome's composition and evolution and the interplay between the gut virome and enteric mucosal immunity and their molecular mechanisms. Our review suggests that future research efforts should focus on unraveling the mechanisms of gut viruses in human homeostasis and pathophysiology and on developing virus-prompted precision therapies.
Identifiants
pubmed: 38005947
pii: v15112271
doi: 10.3390/v15112271
pmc: PMC10674713
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Nutr Healthy Aging. 2018 Jun 15;4(4):267-285
pubmed: 29951588
PLoS Pathog. 2014 Mar 27;10(3):e1003998
pubmed: 24676425
Gut. 2019 Jul;68(7):1169-1179
pubmed: 30842211
PLoS One. 2013 Aug 16;8(8):e71036
pubmed: 23976975
PeerJ. 2019 Apr 10;7:e6695
pubmed: 30993039
Front Microbiol. 2016 Aug 17;7:1267
pubmed: 27582733
Inflamm Bowel Dis. 2014 Mar;20(3):431-43
pubmed: 24487272
Cell Host Microbe. 2019 Feb 13;25(2):195-209
pubmed: 30763534
Front Microbiol. 2023 May 24;14:963173
pubmed: 37293229
Sci Rep. 2015 Nov 12;5:16532
pubmed: 26559140
Mol Biol Rep. 2023 Sep;50(9):7901-7907
pubmed: 37421503
Front Immunol. 2020 Jul 16;11:1513
pubmed: 32765522
Nat Rev Immunol. 2016 May 27;16(6):341-52
pubmed: 27231050
Vaccines (Basel). 2023 Mar 03;11(3):
pubmed: 36992175
Microbiome. 2019 Feb 12;7(1):22
pubmed: 30755267
PeerJ. 2018 May 7;6:e4694
pubmed: 29761040
Nature. 2020 Jan;577(7790):327-336
pubmed: 31942051
Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8
pubmed: 30763538
Front Microbiol. 2019 Jun 04;10:1124
pubmed: 31231319
PeerJ. 2015 May 28;3:e985
pubmed: 26038737
Nature. 2014 Dec 4;516(7529):94-8
pubmed: 25409145
Cell Host Microbe. 2018 Nov 14;24(5):653-664.e6
pubmed: 30449316
Mediators Inflamm. 2015;2015:326032
pubmed: 25944980
Nat Biotechnol. 2019 Dec;37(12):1408-1412
pubmed: 31748692
United European Gastroenterol J. 2019 Oct;7(8):999-1007
pubmed: 31662858
Lancet. 2017 Apr 29;389(10080):1756-1770
pubmed: 27914657
Annu Rev Virol. 2021 Sep 29;8(1):415-435
pubmed: 34014761
Lancet Infect Dis. 2009 Apr;9(4):228-36
pubmed: 19324295
Cell. 2021 Jun 24;184(13):3394-3409.e20
pubmed: 34077752
EMBO Rep. 2019 Jun;20(6):
pubmed: 30952693
Microbiome. 2022 Dec 30;10(1):245
pubmed: 36581858
Microbiome. 2021 Apr 12;9(1):89
pubmed: 33845877
Cell Host Microbe. 2019 Oct 9;26(4):542-550.e5
pubmed: 31561965
J Exp Med. 2014 Nov 17;211(12):2397-410
pubmed: 25366965
Nat Med. 2016 Jul 7;22(7):713-22
pubmed: 27387886
Nat Rev Microbiol. 2021 Aug;19(8):514-527
pubmed: 33785903
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10771-6
pubmed: 23690590
Nat Rev Gastroenterol Hepatol. 2023 Jan;20(1):50-64
pubmed: 35945456
STAR Protoc. 2022 Feb 09;3(1):101170
pubmed: 35199035
Res Microbiol. 2008 Jun;159(5):367-73
pubmed: 18541415
Nutrients. 2021 Jan 07;13(1):
pubmed: 33430497
Nature. 2007 May 17;447(7142):326-9
pubmed: 17507983
Sci Rep. 2017 Aug 14;7(1):8004
pubmed: 28808331
Microbiome. 2018 Aug 20;6(1):145
pubmed: 30126456
Cells. 2019 May 05;8(5):
pubmed: 31060315
Front Immunol. 2021 Mar 18;12:644269
pubmed: 33815397
Science. 2016 Mar 4;351(6277):1083-7
pubmed: 26941318
J Immunol. 2018 Sep 15;201(6):1615-1624
pubmed: 30181300
Medicina (Kaunas). 2023 Mar 17;59(3):
pubmed: 36984595
J Exp Med. 2017 Dec 4;214(12):3687-3705
pubmed: 29089374
Microbiol Mol Biol Rev. 2017 Nov 8;81(4):
pubmed: 29118049
Nat Microbiol. 2023 May;8(5):986-998
pubmed: 37037943
Viruses. 2018 Nov 08;10(11):
pubmed: 30413044
Nat Microbiol. 2019 Apr;4(4):693-700
pubmed: 30692672
Front Cell Infect Microbiol. 2021 Mar 15;11:616918
pubmed: 33791236
ISME J. 2013 Mar;7(3):672-9
pubmed: 23151645
Front Immunol. 2023 Jan 05;13:1079294
pubmed: 36685560
Microbiome. 2016 Jun 23;4(1):29
pubmed: 27338728
N Engl J Med. 2009 Nov 19;361(21):2066-78
pubmed: 19923578
Gut Microbes. 2023 Jan-Dec;15(1):2192522
pubmed: 36998174
Nat Microbiol. 2019 Jul;4(7):1120-1128
pubmed: 30936486
Sci Transl Med. 2016 Jun 15;8(343):343ra82
pubmed: 27306664
Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2114619119
pubmed: 35320047
Nature. 2020 May;581(7809):470-474
pubmed: 32461640
Cell Mol Immunol. 2021 Apr;18(4):889-904
pubmed: 32901128
Cell Host Microbe. 2019 Feb 13;25(2):210-218
pubmed: 30763535
Science. 2016 Mar 18;351(6279):1296-302
pubmed: 26989247
Microbiome. 2021 Mar 29;9(1):78
pubmed: 33781338
Nat Commun. 2018 Jan 10;9(1):141
pubmed: 29321519
Prev Vet Med. 2021 Sep;194:105448
pubmed: 34333413
Front Cell Infect Microbiol. 2021 Jun 30;11:715671
pubmed: 34277478
Science. 2019 Mar 29;363(6434):
pubmed: 30923196
Microbiome. 2023 Aug 28;11(1):193
pubmed: 37635262
Cell. 2010 Jun 25;141(7):1135-45
pubmed: 20602997
Nature. 2019 Nov;575(7783):505-511
pubmed: 31723265
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):
pubmed: 34083435
Curr Opin Organ Transplant. 2019 Dec;24(6):679-686
pubmed: 31577594
EBioMedicine. 2022 Jul;81:104113
pubmed: 35753153
Cell Host Microbe. 2020 Nov 11;28(5):724-740.e8
pubmed: 32841606
J Med Virol. 2018 Jul;90(7):1257-1263
pubmed: 29575060
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4578-85
pubmed: 20668239
Science. 2013 Jul 19;341(6143):295-8
pubmed: 23869020
Front Immunol. 2023 Apr 14;14:1171826
pubmed: 37122757
Clin Exp Allergy. 2013 Dec;43(12):1384-94
pubmed: 24118234
Microorganisms. 2020 Sep 07;8(9):
pubmed: 32906839
Nutrients. 2023 Feb 15;15(4):
pubmed: 36839335
Lancet. 2017 Apr 29;389(10080):1741-1755
pubmed: 27914655
Cell. 2021 Feb 18;184(4):1098-1109.e9
pubmed: 33606979
Gastroenterology. 2021 Oct;161(4):1194-1207.e8
pubmed: 34245762
Microbiome. 2018 Oct 30;6(1):196
pubmed: 30376898
Cell. 2020 Sep 17;182(6):1460-1473.e17
pubmed: 32916129
Gastroenterology. 2022 Sep;163(3):699-711
pubmed: 35679948
Nat Commun. 2022 Sep 6;13(1):5252
pubmed: 36068216
Nature. 2023 Jan;613(7945):639-649
pubmed: 36697862
Microbiome. 2013 Feb 18;1(1):7
pubmed: 24451302
Sci Rep. 2016 Jul 13;6:29697
pubmed: 27405244
Microbiome. 2020 Jun 30;8(1):103
pubmed: 32605663
Gut Microbes. 2017 May 4;8(3):214-220
pubmed: 27935413
Viruses. 2019 Jul 20;11(7):
pubmed: 31330855
Trends Microbiol. 2020 May;28(5):349-359
pubmed: 32298613
Sci Adv. 2020 Feb 07;6(6):eaay5981
pubmed: 32083183
Biomedicines. 2023 Jun 23;11(7):
pubmed: 37509432
Cell Host Microbe. 2019 Oct 9;26(4):527-541.e5
pubmed: 31600503
Nat Cell Biol. 2006 Dec;8(12):1327-36
pubmed: 17128265
Nat Rev Immunol. 2014 Oct;14(10):667-85
pubmed: 25234148
Int J Surg. 2021 Apr;88:105906
pubmed: 33789826
Nat Microbiol. 2020 Oct;5(10):1262-1270
pubmed: 32690954
Nat Med. 2018 Dec;24(12):1822-1829
pubmed: 30374198
Gut Microbes. 2019;10(2):149-158
pubmed: 30252582
Nature. 2019 Oct;574(7776):117-121
pubmed: 31534227
Microbiome. 2018 Oct 26;6(1):193
pubmed: 30367675
JGH Open. 2023 May 24;7(5):337-350
pubmed: 37265934
Microbiome. 2017 Apr 28;5(1):48
pubmed: 28454555
Viruses. 2023 Jan 06;15(1):
pubmed: 36680214
Annu Rev Microbiol. 2012;66:177-96
pubmed: 22994491
Microorganisms. 2019 Nov 28;7(12):
pubmed: 31795262
Gut Microbes. 2021 Jan-Dec;13(1):1-17
pubmed: 33406976
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Inflamm Regen. 2022 Nov 1;42(1):32
pubmed: 36316749
Cell. 2014 Mar 27;157(1):142-50
pubmed: 24679532
Sci Transl Med. 2015 Sep 30;7(307):307ra152
pubmed: 26424567
Curr Opin Virol. 2021 Apr;47:86-94
pubmed: 33652230
PLoS One. 2021 Apr 14;16(4):e0240958
pubmed: 33852569
Virology. 2017 Mar;503:21-30
pubmed: 28110145
Curr Opin Virol. 2022 Jun;54:101231
pubmed: 35643020