Dietary supplementation with nacre reduces cortical bone loss in aged female mice.

Aging is associated with detrimental bone loss leading to fragility fractures in both men and women. Notably, a majority of bone loss with aging is cortical, as well as a large number of fractures are non-vertebral and at the non-hip sites. Nacre is a product of mollusks composed of calcium carbonate embedded in organic components. As our previous study demonstrated the protective effect of nacre supplementation on trabecular bone loss in ovariectomized rats, we sought to evaluate the effect of dietary nacre on bone loss related to aging in female mice which do not suffer true menopause as observed in women. The current study compared the effect of a 90-day long nacre-supplemented diet to that of Standard or CaCO

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Déclaration de conflit d'intérêts

Declaration of competing interest MR provides scientific consultation for Megabiopharma. TT reports receiving lecture fees from Amgen, Arrow, Biogen, BMS, Chugai, Galapagos, Grunenthal, Jansen, LCA, Lilly, MSD, Nordic, Novartis, Pfizer, Sanofi, Thuasne, Theramex, UCB and research grants or investigator's fees from Bone Therapeutics, UC. HM reports fees from Amgen, Arrow, Biogen, BMS, CellTrion, Chugai, Galapagos, Fresenius Kabi, Jansen, Lilly, MSD, Nodic, Novartis, Pfizer, Sanofi, and UCB. All other authors state that they have no conflicts of interest.