Indoleamine 2, 3-dioxygenase-transfected bone marrow-derived mesenchymal stem cells promote corneal allograft survival by inhibiting T cell proliferation: A rat study.
Bone marrow-derived mesenchymal stem cells
Corneal allograft rejection
Indoleamine 2,3-dioxygenase
Journal
Transplant immunology
ISSN: 1878-5492
Titre abrégé: Transpl Immunol
Pays: Netherlands
ID NLM: 9309923
Informations de publication
Date de publication:
24 Nov 2023
24 Nov 2023
Historique:
received:
02
04
2023
revised:
13
11
2023
accepted:
13
11
2023
pubmed:
26
11
2023
medline:
26
11
2023
entrez:
25
11
2023
Statut:
aheadofprint
Résumé
Allograft rejection is still the main cause of corneal transplantation failure. Therefore, we investigated the role of indoleamine 2,3-dioxygenase (IDO)-transfected bone marrow-derived mesenchymal stem cells (IDO-BMSCs) in corneal allograft rejection in rats. IDO-BMSCs were constructed and co-cultured with CD4 The lentivirus-mediated IDO gene was successfully transfected into BMSCs, which stably secreted the IDO protein. The proliferation of CD4 Our results suggest that IDO-BMSC treatment enhances the direct immunomodulatory effect of corneal allograft transplants in rats, promoting corneal allograft survival by inhibiting the proliferation of CD4
Identifiants
pubmed: 38007171
pii: S0966-3274(23)00177-6
doi: 10.1016/j.trim.2023.101960
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101960Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.