CLIC1 regulation of cancer stem cells in glioblastoma.

Humans Glioblastoma / drug therapy Neoplastic Stem Cells / metabolism Chloride Channels / metabolism
Angiogenesis Cancer stem cells Chloride intracellular channel 1 Glioblastoma Invasion Migration Proliferation Reactive oxygen species Self-renewal

Journal

Current topics in membranes
ISSN: 1063-5823
Titre abrégé: Curr Top Membr
Pays: United States
ID NLM: 9212591

Informations de publication

Date de publication:
2023
Historique:
medline: 27 11 2023
pubmed: 26 11 2023
entrez: 25 11 2023
Statut: ppublish

Résumé

Chloride intracellular channel 1 (CLIC1) has emerged as a therapeutic target in various cancers. CLIC1 promotes cell cycle progression and cancer stem cell (CSC) self-renewal. Furthermore, CLIC1 is shown to play diverse roles in proliferation, cell volume regulation, tumour invasion, migration, and angiogenesis. In glioblastoma (GB), CLIC1 facilitates the G1/S phase transition and tightly regulates glioma stem-like cells (GSCs), a rare population of self-renewing CSCs with central roles in tumour resistance to therapy and tumour recurrence. CLIC1 is found as either a monomeric soluble protein or as a non-covalent dimeric protein that can form an ion channel. The ratio of dimeric to monomeric protein is altered in GSCs and depends on the cell redox state. Elucidating the mechanisms underlying the alterations in CLIC1 expression and structural transitions will further our understanding of its role in GSC biology. This review will highlight the role of CLIC1 in GSCs and its significance in facilitating different hallmarks of cancer.

Identifiants

DOI: 10.1016/bs.ctm.2023.09.004 PMID: 38007271
pubmed: 38007271
pii: S1063-5823(23)00025-X
doi: 10.1016/bs.ctm.2023.09.004
pii:
doi:

Substances chimiques

Chloride Channels 0
CLIC1 protein, human 0

Types de publication

Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

99-123

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Auteurs

Kamaldeep Randhawa (K)

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.

Arezu Jahani-Asl (A)

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada; Regenerative Medicine Program and Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: arezu.jahani@uottawa.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CLIC1 regulation of cancer stem cells in glioblastoma.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › CLIC1 regulation of cancer stem cells in glioblastoma.
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › CLIC1 regulation of cancer stem cells in glioblastoma.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux chlorure › CLIC1 regulation of cancer stem cells in glioblastoma.