NEUROIMAGING FINDINGS IN FETAL HEMIMEGALENCEPHALY: CASE STUDY AND REVIEW.
Journal
Fetal diagnosis and therapy
ISSN: 1421-9964
Titre abrégé: Fetal Diagn Ther
Pays: Switzerland
ID NLM: 9107463
Informations de publication
Date de publication:
25 Nov 2023
25 Nov 2023
Historique:
received:
29
08
2023
accepted:
17
11
2023
medline:
27
11
2023
pubmed:
27
11
2023
entrez:
26
11
2023
Statut:
aheadofprint
Résumé
Limited information exists in the prenatal literature regarding the neuroimaging features of fetal hemimegalencephaly. This report describes ultrasound and magnetic resonance imaging (MRI) findings in a second-trimester fetus with an isolated, severe form of hemimegalencephaly. The most prominent imaging findings included unilateral enlarged cerebral hemisphere and ipsilateral ventriculomegaly causing cerebral asymmetry, midline shift and macrocephaly. Abnormal cortical development imaging signs were also evident. A literature review encompassing 23 reports describing 36 cases, including ours, is presented. Characteristic ultrasound findings for the diagnosis of hemimegalencephaly are not always apparent prenatally. Asymmetric ventriculomegaly emerges as the most common but nonspecific presenting feature during routine second- or third-trimester ultrasound scans. Subsequent high-resolution prenatal neurosonography and fetal MRI facilitate definitive prenatal diagnosis, showcasting associated features primarily related to cortical migration, differentiation, and maturation. Postnatally, the prognosis is poor due to intractable seizures, hemiplegia and progressive neurodevelopmental delay.
Sections du résumé
BACKGROUND
BACKGROUND
Limited information exists in the prenatal literature regarding the neuroimaging features of fetal hemimegalencephaly.
SUMMARY
CONCLUSIONS
This report describes ultrasound and magnetic resonance imaging (MRI) findings in a second-trimester fetus with an isolated, severe form of hemimegalencephaly. The most prominent imaging findings included unilateral enlarged cerebral hemisphere and ipsilateral ventriculomegaly causing cerebral asymmetry, midline shift and macrocephaly. Abnormal cortical development imaging signs were also evident. A literature review encompassing 23 reports describing 36 cases, including ours, is presented.
KEY MESSAGES
CONCLUSIONS
Characteristic ultrasound findings for the diagnosis of hemimegalencephaly are not always apparent prenatally. Asymmetric ventriculomegaly emerges as the most common but nonspecific presenting feature during routine second- or third-trimester ultrasound scans. Subsequent high-resolution prenatal neurosonography and fetal MRI facilitate definitive prenatal diagnosis, showcasting associated features primarily related to cortical migration, differentiation, and maturation. Postnatally, the prognosis is poor due to intractable seizures, hemiplegia and progressive neurodevelopmental delay.
Identifiants
pubmed: 38008087
pii: 000535406
doi: 10.1159/000535406
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
S. Karger AG, Basel.