Phosphatidylserine promotes immunotherapy for airway allergy.

Airway allergy Immunotherapy Phosphatidylserine Regulatory T cells Tr1 cells

Journal

Immunology letters
ISSN: 1879-0542
Titre abrégé: Immunol Lett
Pays: Netherlands
ID NLM: 7910006

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 02 06 2023
revised: 06 11 2023
accepted: 23 11 2023
pubmed: 27 11 2023
medline: 27 11 2023
entrez: 26 11 2023
Statut: ppublish

Résumé

Type 1 regulatory T cells (Tr1 cells) play an important role in the maintenance of the immune homeostasis in the body. The induction of Tr1 cell is to be further investigated. The interaction of phosphatidylserine (PS) with TIM3 has immune regulation functions. The objective of this study is to elucidate the role of PS-TIM3 signals in inducing Tr1 cells. In this study, mice were treated using PS or specific immunotherapy by nasal instillation. A murine model of allergic rhinitis was developed using ovalbumin as a specific antigen. We found that PS-containing nasal instillation induced Tr1 cells in the airway tissues. PS promoted gene activities associated with IL-10 through activation of TIM3 in CD4

Identifiants

DOI: 10.1016/j.imlet.2023.11.006 PMID: 38008186
pubmed: 38008186
pii: S0165-2478(23)00193-1
doi: 10.1016/j.imlet.2023.11.006
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-55

Informations de copyright

Copyright © 2023 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None to declare.

Auteurs

Jinmei Xue (J)

Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, China.

Limin Suo (L)

Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, China.

Yunfang An (Y)

Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, China.

Xinxin Wang (X)

Guangdong Provincial Regional Disease Key Laboratory, Shenzhen, China; Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, Shenzhen, China.

Shuang Zhang (S)

Guangdong Provincial Regional Disease Key Laboratory, Shenzhen, China; Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, Shenzhen, China.

Huazhen Liu (H)

Guangdong Provincial Regional Disease Key Laboratory, Shenzhen, China; Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, Shenzhen, China.

Yongjin Wu (Y)

Department of General Practical Medicine, Third Affiliated Hospital, Shenzhen, China.

Xizhuo Sun (X)

Department of General Practical Medicine, Third Affiliated Hospital, Shenzhen, China.

Changqing Zhao (C)

Department of Otolaryngology, Head & Neck Surgery, Second Hospital, Shanxi Medical University, Taiyuan, China. Electronic address: fahyj@126.com.

Pingchang Yang (P)

Guangdong Provincial Regional Disease Key Laboratory, Shenzhen, China; Institute of Allergy & Immunology, Shenzhen University School of Medicine, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, Shenzhen, China; Department of General Practical Medicine, Third Affiliated Hospital, Shenzhen, China. Electronic address: pcy2356@szu.edu.cn.

Classifications MeSH