Challenges in recombinant brain-derived neurotrophic factor production.
expression systems
pharmaceutical biotechnology
recombinant proteins
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
25 Nov 2023
25 Nov 2023
Historique:
received:
28
08
2023
revised:
05
11
2023
accepted:
06
11
2023
medline:
27
11
2023
pubmed:
27
11
2023
entrez:
26
11
2023
Statut:
aheadofprint
Résumé
Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.
Identifiants
pubmed: 38008688
pii: S0167-7799(23)00325-6
doi: 10.1016/j.tibtech.2023.11.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.