Therapeutic effect of intraperitoneal dexamethasone on noise-induced permanent threshold shift in mice model.
Auditory brainstem response
Dexamethasone
Noise-induced hearing loss
Permanent threshold shift
Journal
Experimental brain research
ISSN: 1432-1106
Titre abrégé: Exp Brain Res
Pays: Germany
ID NLM: 0043312
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
received:
30
05
2023
accepted:
17
10
2023
medline:
27
11
2023
pubmed:
27
11
2023
entrez:
27
11
2023
Statut:
aheadofprint
Résumé
The purpose of the study was to which investigate whether dexamethasone, which has anti-inflammatory and immune response suppression roles, could treat noise-induced hearing loss caused by damage to hair cells in the cochlea. The experiment used 8-week-old CBA mice exposed to white noise at an intensity of 110 dB SPL for 2 h, with hearing loss confirmed by the auditory brainstem response test. Dexamethasone was administered by intraperitoneal injection for 5 days, and the therapeutic effect was investigated for 3 weeks. The experimental groups were 3 mg/kg of dexamethasone (3 mpk) and 10 mg/kg of dexamethasone (10 mpk), and the control group was a saline-administered group. The results showed that compared to the control group, the hearing threshold value was recovered by 10 dB SPL compared to the saline group from the 14th day in the 3 mpk group. In the 10 mpk group, thresholds were recovered from the 7th day compared to the saline group. This difference was similar at 4 kHz, and in the case of the 10 mpk group, the threshold was recovered by 20 dB SPL compared to the saline group. The study also confirmed the restoration of nerve cell activity and showed a recovery effect of about 20 µV in the amplitude value change in the 10 mpk group. In conclusion, the study suggests that dexamethasone has a therapeutic effect for noise-induced hearing loss by increasing the activity of nerve cells and showing a recovery effect from hair cells damaged by noise.
Identifiants
pubmed: 38010535
doi: 10.1007/s00221-023-06742-2
pii: 10.1007/s00221-023-06742-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and ICT, South Korea
ID : 2020R1A2C2003529
Organisme : Ministry of Science and ICT, South Korea
ID : 2022R1A2C3003700
Organisme : Ministry of Science and ICT, South Korea
ID : 2022R1F1A1068420
Organisme : Ministry of Science and ICT, South Korea
ID : 2022M3E5F2017487
Organisme : Ministry of Health and Welfare
ID : HR22C1832
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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