Filamin A is involved in human intrahepatic cholangiocarcinoma aggressiveness and progression.
calpeptin
cholangiocarcinoma
cleavage
cytoskeleton
liver cancer
Journal
Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
revised:
19
10
2023
received:
05
04
2023
accepted:
12
11
2023
medline:
27
11
2023
pubmed:
27
11
2023
entrez:
27
11
2023
Statut:
aheadofprint
Résumé
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver tumour, characterized by poor prognosis and lack of effective therapy. The cytoskeleton protein Filamin A (FLNA) is involved in cancer progression and metastasis, including primary liver cancer. FLNA is cleaved by calpain, producing a 90 kDa fragment (FLNA We evaluated the expression and localization of FLNA and FLNA These findings demonstrate that FLNA is involved in human iCCA progression and calpeptin strongly decreased FLNA
Sections du résumé
BACKGROUND & AIMS
OBJECTIVE
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver tumour, characterized by poor prognosis and lack of effective therapy. The cytoskeleton protein Filamin A (FLNA) is involved in cancer progression and metastasis, including primary liver cancer. FLNA is cleaved by calpain, producing a 90 kDa fragment (FLNA
METHODS & RESULTS
RESULTS
We evaluated the expression and localization of FLNA and FLNA
CONCLUSIONS
CONCLUSIONS
These findings demonstrate that FLNA is involved in human iCCA progression and calpeptin strongly decreased FLNA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
Informations de copyright
© 2023 The Authors. Liver International published by John Wiley & Sons Ltd.
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