Correlations Among Clinical Phenotypes, Radiological Examination Indexes, and Hearing Status in Congenital Microtia.
Journal
The Journal of craniofacial surgery
ISSN: 1536-3732
Titre abrégé: J Craniofac Surg
Pays: United States
ID NLM: 9010410
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
received:
06
05
2023
accepted:
26
08
2023
medline:
27
11
2023
pubmed:
27
11
2023
entrez:
27
11
2023
Statut:
aheadofprint
Résumé
Microtia is a congenital malformation of the external ear that often presents with other anatomical abnormalities and ipsilateral hearing loss (HL). The aim of this study was to present the correlation among important phenotypic abnormalities in microtia and their relationship with HL in a clinical population in China. In this study, a retrospective analysis was conducted on 307 patients diagnosed with microtia who visited the Department of Auricular Reconstruction of the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, for surgical auricle reconstruction from April 2021 to April 2022. Standardized classification of ear malformations, craniofacial CT scans, and pure tone audiometric data were collected, and statistical analyses were performed using the rank sum test, Kruskal-Wallis test, and Spearman's rank correlation coefficient. The results showed that group differences between ear malformation and variations in the development of mandible, external auditory canal (EAC), and mastoid pneumatization were statistically significant and each had a positive correlation. Among them, the correlation between development of ear and EAC was the most significant (Ρ=0.72). Besides, the severity of HL (97% were conductive) was positively correlated with ear and EAC dysplasia with or without mandibular hypoplasia. Based on the statistical analysis of the correlation between ear malformation and HL, the authors strongly recommend that facial phenotype reconstruction and hearing improvement of microtia should be considered comprehensively, regardless of whether children with microtia show HL or not, early diagnosis of audiology evaluation and appropriate intervention measures should be implemented.
Identifiants
pubmed: 38011621
doi: 10.1097/SCS.0000000000009867
pii: 00001665-990000000-01251
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright © 2023 by Mutaz B. Habal, MD.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Bess FH, Davis H, Camarata S, et al. Listening-related fatigue in children with unilateral hearing loss. Lang, Speech, Hear Serv Sch 2020;51:84–97
Zhang Y, Jiang H, Yang Q, et al. Microtia in a Chinese specialty clinic population: clinical heterogeneity and associated congenital anomalies. Plast Reconstr Surg 2018;142:892e–903e
Bouhadana G, Gornitsky J, Saleh E, et al. Surgical microtia reconstruction in hemifacial microsomia patients: current state and future directions. Plast Reconstr Surg Glob Open 2022;10:e4486
Tonn CR, Grundfast KM. What an otolaryngologist should know about evaluation of a child referred for delay in speech development. JAMA Otolaryngol Head Neck Surg 2014;140:259–265
Carpenter D, Dougherty W, Sindhar S, et al. Are children with unilateral hearing loss more tired? Int J Pediatr Otorhinolaryngol 2022;155:111075
Yang I-H, Chung JH, Yim S, et al. Distribution and phenotypes of hemifacial microsomia and its association with other anomalies. Korean J Orthod 2020;50:33–41
Xie J, He L, Gong SS. Interpretation and thought on the WHO World Report on Hearing. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021;56:1131–1135
Collett BR, Wallace ER, Kapp-Simon KA, et al. Cognitive, motor, and language development of preschool children with craniofacial microsomia. Cleft Palate Craniofac J 2021;58:1169–1177
Dimitrov L, Gossman W. Pediatric Hearing Loss. Treasure Island (FL): StatPearls; 2022
Edlund RK, Birol O, Groves AK. The role of foxi family transcription factors in the development of the ear and jaw. Curr Top Dev Biol 2015;111:461–495
Shen P, Chen L, Zhang D, et al. Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs. NPJ Regen Med 2022;7:69
Tuin AJ, Tahiri Y, Paine KM, et al. Clarifying the relationships among the different features of the OMENS+ classification in craniofacial microsomia. Plast Reconstr Surg 2015;135:149e–156e
Zhang Z, Li X, Chen X, et al. Correlations between mandible condylar structures and external ear deformities in hemifacial microsomia with three-dimensional analysis. J Craniofac Surg 2022;33:1154–1158
Takano K, Takahashi N, Ogasawara N, et al. The association of external and middle ear anomaly and mandibular morphology in congenital microtia. Otol Neurotol 2016;37:889–894
Wan J, Meara JG, Kovanlikaya A, et al. Clinical, radiological, and audiological relationships in hemifacial microsomia. Ann Plast Surg 2003;51:161–166
Jin L, Hao S, Fu Y, et al. Clinical analysis based on 208 patients with microtia (especially reviewed oculo-auriculo-vertebral spectrum, hearing test, CT scan). Turk J Pediatr 2010;52:582–587
Mitchell RM, Saltzman BS, Norton SJ, et al. Hearing loss in children with craniofacial microsomia. Cleft Palate Craniofac J 2017;54:656–663
Chen K, Liu L, Shi R, et al. Correlation among external auditory canal anomaly, temporal bone malformation, and hearing levels in patients with microtia. Ear Nose Throat J 2017;96:210–217
Arras T, Boudewyns A, Swinnen F, et al. Longitudinal auditory data of children with prelingual single-sided deafness managed with early cochlear implantation. Sci Rep 2022;12:9376
Suutarla S, Rautio J, Ritvanen A, et al. Microtia in Finland: comparison of characteristics in different populations. Int J Pediatr Otorhinolaryngol 2007;71:1211–1217