[Inflammatory indexes and their association with the severity of preeclampsia].

Background

Recent studies have confirmed the relationship between some inflammatory indexes and preeclampsia (PE); however, they have not been analyzed in PE with and without severity criteria.

Objective

To know the association between inflammatory indexes and the severity of PE.

Material and methods

Analytical cross-sectional prolective study. Pregnant patients were included, divided into group 1 (PE without severity criteria); group 2 (PE with severity criteria); group 3 (normotensive pregnant women). Records were reviewed and inflammatory indexes [(neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], lymphocyte-monocyte ratio [LMR] and systemic immune index [SII]) were calculated.

Results

240 patients were analyzed, 80 per group; age 28 (IQR 27-29) years. A significant difference was observed between group 1, group 2 and group 3, NLR 3.29 (IQR 2.82-3.69), 3.59 (IQR 2.83-4.2) and 3.42 (IQR 3.17-3.92), respectively, p = 0.02; PLR 121.59 (IQR 103.78-132), 108.32 (IQR 92.96-127.43) 136 (IQR 115.18-157.56), respectively, p = 0.01; LMR and SII showed no difference between the groups. LMR made possible to distinguish PE with and without severity criteria, cut-off point of ≥ 3.20, sensitivity 56%, specificity 56%, AUC 0.56, p = 0.01, and cut-off point ≥ 3.24, sensitivity 58%, specificity 58%, AUC 0.57, p = 0.04, respectively; the LMR ≥ 3.24 was associated with PE without severity criteria (OR 2.02 [95%CI 1.08-3.80], p = 0.03).

Conclusions

The MLR was the only inflammatory index analyzed that was associated with the presence of PE without severity data. No inflammatory index was associated with PE with severity data.

Introducción

estudios recientes han confirmado la relación que existe entre algunos índices inflamatorios y la preeclampsia (PE); sin embargo, no se han analizado en la PE con y sin criterios de severidad.

Objetivo

conocer la asociación entre los índices inflamatorios y la severidad de la PE.

Material y métodos

estudio transversal analítico prolectivo. Se incluyeron pacientes embarazadas, distribuidas en PE sin criterios de severidad (grupo 1), PE con criterios de severidad (grupo 2) y normotensión (grupo 3). Se revisaron expedientes y se calcularon los índices inflamatorios (índice neutrófilos linfocitos [INL], plaquetas linfocitos [IPL], linfocito monocito [ILM] e inmunosistémico [IIS]).

Resultados

se analizaron 240 pacientes, 80 por grupo; edad de 28 años (RIC 27-29). Se observó diferencia significativa entre grupo 1, grupo 2 y grupo 3, INL 3.29 (RIC 2.82-3.69), 3.59 (RIC 2.83-4.2) y 3.42 (RIC 3.17-3.92), respectivamente, p = 0.02; IPL 121.59 (RIC 103.78-132), 108.32 (RIC 92.96-127.43) 136 (RIC 115.18-157.56), respectivamente, p = 0.01; ILM y ISS no mostraron diferencia entre los grupos. ILM permitió distinguir PE con y sin criterios de severidad, punto de corte ≥ 3.20, sensibilidad 56%, especificidad 56%, AUC 0.56, p = 0.01, y, punto de corte ≥ 3.24, sensibilidad 58%, especificidad 58%, AUC 0.57, p = 0.04, respectivamente; el ILM ≥ 3.24 se asoció con PE sin criterios de severidad (RM 2.02 [IC 95% 1.08-3.80], p = 0.03).

Conclusiones

el ILM fue el único índice inflamatorio analizado que se asoció con la presencia de PE sin criterios de severidad. Ningún índice inflamatorio se asoció con la PE con datos de severidad.

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