Medication adherence in pediatric kidney transplantation: How to build a bridge over troubled water.
non-adherence
Journal
Pediatric transplantation
ISSN: 1399-3046
Titre abrégé: Pediatr Transplant
Pays: Denmark
ID NLM: 9802574
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
revised:
13
10
2023
received:
26
07
2023
accepted:
16
11
2023
medline:
28
11
2023
pubmed:
28
11
2023
entrez:
27
11
2023
Statut:
aheadofprint
Résumé
Adhering to the immunosuppressive regimen remains one of the biggest challenges for children and adolescents after kidney transplantation. The first paper on nonadherence, co-authored by Dr. Fine, appeared in Pubmed over 45 years ago. Since then, many clinicians and researchers tried to better understand nonadherence and are looking for effective ways to support young people in implementing the complex medication regimen in their daily lives. As a tribute to Dr. Fine, we conducted a comprehensive review providing an overview of adherence-enhancing interventions in the field of pediatric kidney transplantation, thereby focusing on strategies that not only are effective but can also be embedded in daily clinical practice successfully and sustainably. This overview is preceded by a discussion about how to find out who is in need of supportive interventions. We will also argue that interventions should already start before pediatric kidney transplantation and discuss how to decide whether or not a young patient with nonadherence-induced graft loss should undergo retransplantation. We hope this comprehensive overview will rekindle the hope that we can finally turn the tide and beat one of pediatric kidney transplantation's main enemies.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14663Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
Ratcliff MB, Blount RL, Mee LL. The relationship between adolescent renal transplant recipients' perceived adversity, coping, and medical adherence. J Clin Psychol Med Settings. 2010;17(2):116-124.
Claes A, Decorte A, Levtchenko E, Knops N, Dobbels F. Facilitators and barriers of medication adherence in pediatric liver and kidney transplant recipients: a mixed-methods study. Prog Transplant. 2014;24(4):311-321.
Korsch BM, Negrete VF, Gardner JE, et al. Kidney transplantation in children: psychosocial follow-up study on child and family. J Pediatr. 1973;83(3):399-408.
Rickard M, Hannick JH, Fernandez N, Koyle MA, MacMurdo K, Lorenzo AJ. Publication trends in pediatric renal transplantation: bibliometric analysis of literature from 1050 to 2017. Pediatr Transplant. 2019;23(5):e13455.
Dobbels F, Ruppar T, De Geest S, et al. Adherence to the immunosuppressive regimen in pediatric kidney transplant recipients: a systematic review. Pediatr Transplant. 2010;14(5):603-613.
Killian MO, Schuman DL, Mayersohn GS, Triplett KN. Psychosocial predictors of medication non-adherence in pediatric organ transplantation: a systematic review. Pediatr Transplant. 2018;22(4):e13188.
Chisholm-Burns MA, Spivey CA, Rehfeld R, Zawaideh M, Roe DJ, Gruessner R. Immunosuppressant therapy adherence and graft failure among pediatric renal transplant recipients. Am J Transplant. 2009;9(11):2497-2504.
Foster BJ, Dahhou M, Zhang X, Platt RW, Samuel SM, Hanley JA. Association between age and graft failure rates in young kidney transplant recipients. Transplantation. 2011;92(11):1237-1243.
Hara S. Current pathological perspectives on chronic rejection in renal allografts. Clin Exp Nephrol. 2016;21(6):943-951.
Ritchie AG, Clayton PA, McDonald SP, et al. Age-specific risk of renal graft loss from late acute rejection or non-compliance in the adolescent and young adult period. Nephrol Ther. 2018;23(6):585-591.
Bobanga JD, Vogt BA, Woodside KJ, et al. Outcome differences between young children and adolescents undergoing kidney transplantation. J Pediatr Surg. 2015;50(6):996-999.
Akchurin OM, Melamed ML, Hashim BL, Kaskel FJ, del Rio M. Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. Pediatr Transplant. 2014;18(5):538-548.
Fernandez HE, Amaral S, Shaw PA, et al. The effect of transfer to adult transplant care on kidney function and immunosuppressant drug level variability in pediatric kidney transplant recipients. Pediatr Transplant. 2019;23(6):e13527.
Kindem IA, Bjerre A, Hammarstrom C, et al. Kidney-transplanted adolescents - nonadherence and graft outcomes during the transition phase: a nationwide analysis, 2000-2020. Transplantation. 2023;107(5):1206-1212.
McCormick King ML, Mee LL, Gutierrez-Colina AM, et al. Emotional functioning, barriers, and medication adherence in pediatric transplant recipients. J Pediatr Psychol. 2014;39(3):283-293.
Wurm F, McKeaveney C, Corr M, Wilson A, Noble H. The psychosocial needs of adolescent and young adult kidney transplant recipients, and associated interventions: a scoping review. BMC Psychol. 2022;10(1):186.
Biernacka M, Jakubowska-Winecka A, Kalicinski P. Influence of parental attitudes on formation of psychological resilience and adherence to medical regime in adolescents after liver or renal transplantation. Children. 2021;8(8):619.
Boucquemont J, Pai ALH, Dharnidharka VR, et al. Association between day of the week and medication adherence among adolescent and young adult kidney transplant recipients. Am J Transplant. 2020;20(1):274-281.
Dabirzadeh A, Dahhou M, Zhang X, et al. Care processes and structures associated with higher medication adherence in adolescent and young adult transplant recipients. Pediatr Transplant. 2021;25(8):e14106.
Shemesh E, Fine RN. Is calculating the standard deviation of tacrolimus blood levels the new gold standard for evaluating nonadherence to medications in transplant recipients? Pediatr Transplant. 2010;14(8):940-943.
Pollock-Barziv SM, Finkelstein Y, Manlhiot C, et al. Variability in tracrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children. Pediatr Transplant. 2010;14(8):968-975.
Hsiau M, Fernandez HE, Gjertson D, Ettenger RB, Tsai EW. Monitoring nonadherence and acute rejection with variation in blood immunosuppressant levels in pediatric renal transplantation. Transplantation. 2011;92(8):918-922.
Al-Uzri A, Freeman KA, Wade J, et al. Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation. Pediatr Transplant. 2017;21(6):e12983.
Foster BJ, Pai ALH, Zelikovsky N, et al. A randomized trial of a multicomponent intervention to promote medication adherence: the teen adherence in kidney transplant effectiveness of intervention trial (TAKE-IT). Am J Kidney Dis. 2018;72(1):30-41.
Pai ALH, Rausch J, Tackett A, Marsolo K, Drotar D, Goebel J. System for integrated adherence monitoring: real-time non-adherence risk assessment in pediatric kidney transplantation. Pediatr Transplant. 2012;16(4):329-334.
Varnell CD, Rich KL, Nichols M, et al. Assessing barriers to adherence in routine clinical care for pediatric kidney transplant patients. Pediatr Transplant. 2017;21(7):e13027.
Zelikovsky N, Dobson T, Norman J. Medication beliefs and perceived barriers in adolescent renal transplant patients and their parents. Pediatr Nephrol. 2011;26(6):953-959.
Simons LE, McCormick ML, Devine K, et al. Medication barriers predict adolescent transplant recipients' adherence and clinical outcomes at 18-month follow-up. J Pediatr Psychol. 2010;35(9):1038-1048.
Ingerski L, Perrazo L, Goebel J, Pai ALH. Family strategies for achieving medication adherence in pediatric kidney transplantation. Nurs Res. 2011;69(3):190-196.
https://www.iph.nl/en/
Fine R, Becker Y, De Geest S, et al. Nonadherence consensus conference summary report. Am J Transplant. 2009;9(1):35-41.
Fennell RS, Foulkes LM, Boggs SR. Family-based program to promote medication compliance in renal transplant children. Transplant Proc. 1994;26(1):102-103.
Kahana S, Drotar D, Frazier T. Meta-analysis of psychological interventions to promote adherence to treatment in pediatric chronic health conditions. J Pediatr Psychol. 2008;33(6):590-611.
Korus M, Cruchley E, Calic M, et al. Assessing the acceptability and efficacy of teens taking charge: transplant - a pilot randomized control trial. Pediatr Transplant. 2020;24(1):e13612.
Browning RB, McGillicuddy JW, Treiber FA, et al. Kidney transplant recipients' attitudes about using mobile health technology for managing and monitoring medication therapy. J Am Pharm Assoc. 2016;56(4):450-454.
Vanhoof JMM, Vandenberghe B, Geerts D, et al. Technology experience of solid organ transplant patients and their overall willingness to use interactive health technology. J Nurs Scholarship. 2018;50(2):151-162.
Han A, Min S, Ahn S, et al. Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: a randomized controlled trial. PloS One. 2019;14(11):e0224595.
Nguyen C, Dew MA, Irizarry T, et al. Promoting medication adherence from the perspective of adolescent and young adult kidney transplant recipients, parents, and health care professionals: a TAKE-IT TOO study. Pediatr Transplant. 2020;24(5):e13709.
Bamford J, Wirz L. Piloting psychology annual reviews as a method of measuring psychological distress and quality of life in pediatric renal transplant patients. Biomed Res Int. 2016;2016:1685362.
Blum RW, Garell D, Hodgman CH, et al. Transition from child centered to adult health-care systems for adolescents with chronic conditions: A position paper of the Society for Adolescent Medicine. J Adolesc Health. 1993;14(7):570-576.
Harden PN, Walsh G, Bandler N, et al. Bridging the gap: an integrated paediatric to adult clinical service for young adults with kidney failure. BMJ. 2012;344:e3718.
Prestidge C, Romann A, Djurdjev O, Matsuda-Abedini M. Utility and cost of a renal transplant transition clinic. Pediatr Nephrol. 2012;27(2):295-302.
Weitz M, Heeringa S, Neuhaus TJ, Fehr T, Laube GF. Standardized multilevel transition program: does it affect renal transplant outcome? Pediatr Transplant. 2015;19(7):691-697.
Wildes DM, Costigan CS, Kinlough M, et al. Transitional care models in adolescent kidney transplant recipients - a systematic review. Nephrol Dial Transplant. 2023;38(1):49-55.
Nagra A, McGinnity PM, Davis N, et al. Implementing transition: ready steady go. Arch Dis Child Educ Pract ed. 2015;100(6):313-320.
Watson AR, Harden PN, Ferris ME, et al. Transition from pediatric to adult renal services: a consensus statement by the International Society of Nephrology (ISN) and the international pediatric nephrology association (IPNA). Kidney Int. 2011;80(7):704-707.
Hooper DK, Varnell CD Jr, Rich K, et al. A medication adherence promotion system to reduce late kidney allograft rejection: a quality improvement study. Am J Kidney Dis. 2022;79(3):335-346.
Varnell CD Jr, Rich KL, Modi AC, Hooper DK, Eckman MH. A cost-effectiveness analysis of adherence promotion strategies to improve rejection rates in adolescent kidney transplant recipients. Am J Kidney Dis. 2022;80(3):330-340.
Miller WR, Rollnick S. Motivational Interviewing: Helping People to Change. 3rd ed. Guilford Press; 2013.
Lundahl B, Moleni T, Burke BL, et al. Motivational interviewing in medical care settings: a systematic review and meta-analysis of randomized controlled trials. Patient Educ Couns. 2013;93(2):157-168.
Papus M, Dima AL, Viprey M, Schott AM, Schneider MP, Novais T. Motivational interviewing to support medication adherence in adults with chronic condition: systematic review of randomized controlled trials. Patient Educ Couns. 2022;105(11):3186-3203.
Kaltman S, Tankersley A. Teaching motivational interviewing to medical students: a systematic review. Acad Med. 2020;95(3):458-469.
Miller WR, Yahne CE, Moyers TB, Martinez J, Pirritano M. A randomized trial of methods to help clinicians learn motivational interviewing. J Consult Clin Psychol. 2004;72(6):1050-1062.
Butani L, Perez RV. Effect of pretransplant dialysis modality and duration on long-term outcomes of children receiving renal transplants. Transplantation. 2011;91(4):447-451.
Dobbels F, Vanhaecke J, Dupont L, et al. Pretransplant predictors of posttransplant adherence and clinical outcome: an evidence base for pretransplant psychosocial screening. Transplantation. 2009;87(10):1497-1504.
Sawinski D, Lindner H, Fitzsimmons R, et al. Dialysis nonadherence and kidney transplant outcomes: a retrospective cohort study. Am J Kidney Dis. 2022;80(1):46-54.
Freischlag KW, Chen V, Nagaraj SK, et al. Psychosocial assessment of candidates for transplantation (PACT) score identifies high risk patients in pediatric renal transplantation. Front Pediatr. 2019;7:102.
West KB, Plevinsky JM, Amaral S, Laskin B, Lefkowitz DS. Predicting psychosocial risk in pediatric kidney transplantation: an exploratory cluster analysis of a revised pediatric transplant rating instrument. Pediatr Transplant. 2023;27(2):e14454.
Olbrisch ME, Levenson JL, Hamer R. The PACT: a rating scale for the study of clinical decision-making in psychosocial screening of organ transplant candidates. Clin Transplant. 1989;3:164-169.
Zelikovsky N, Schast AP, Palmer JA, Meyers KEC. Perceived barriers to adherence among adolescent renal transplant candidates. Pediatr Transplant. 2008;12(3):300-308.
Graves RC, Fine RN. Kidney retransplantation in children following rejection and recurrent disease. Pediatr Nephrol. 2016;31(12):2235-2247.
Dobbels F, Hames A, Aujoulat I, Heaton N, Samyn M. Should we retransplant a patient who is nonadherent? A literature review and critical reflection. Pediatr Transplant. 2012;16(1):4-11.
Van Arendonk KJ, Garonzik Wang JM, Deshpande NA, et al. Practice patterns and outcomes in retransplantation among pediatric kidney transplant recipients. Transplantation. 2013;95(11):1360-1368.
Manickavasagar R, Wong G, Alexander SI, et al. Allograft outcome following repeat transplantation of patients with non-adherence-related first kidney allograft failure: a population cohort study. Transpl Int. 2019;32(12):1247-1258.