Fabrication of angstrom-scale two-dimensional channels for mass transport.
Journal
Nature protocols
ISSN: 1750-2799
Titre abrégé: Nat Protoc
Pays: England
ID NLM: 101284307
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
received:
03
01
2023
accepted:
31
08
2023
medline:
28
11
2023
pubmed:
28
11
2023
entrez:
27
11
2023
Statut:
aheadofprint
Résumé
Fluidic channels at atomic scales regulate cellular trafficking and molecular filtration across membranes, and thus play crucial roles in the functioning of living systems. However, constructing synthetic channels experimentally at these scales has been a significant challenge due to the limitations in nanofabrication techniques and the surface roughness of the commonly used materials. Angstrom (Å)-scale slit-like channels overcome such challenges as these are made with precise control over their dimensions and can be used to study the fluidic properties of gases, ions and water at unprecedented scales. Here we provide a detailed fabrication method of the two-dimensional Å-scale channel devices that can be assembled to contain a desired number of channels, a single channel or up to hundreds of channels, made with atomic-scale precision using layered crystals. The procedure includes the fabrication of the substrate, flake, spacer layer, flake transfers, van der Waals assembly and postprocessing. We further explain how to perform molecular transport measurements with the Å-channels to directly probe the intriguing and anomalous phenomena that help shed light on the physics governing ultra-confined transport. The procedure requires a total of 1-2 weeks for the fabrication of the two-dimensional channel device and is suitable for users with prior experience in clean room working environments and nanofabrication.
Identifiants
pubmed: 38012396
doi: 10.1038/s41596-023-00911-x
pii: 10.1038/s41596-023-00911-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : RCUK | Engineering and Physical Sciences Research Council (EPSRC)
ID : EP/V048112/1
Organisme : RCUK | Engineering and Physical Sciences Research Council (EPSRC)
ID : EP/W006502/1
Organisme : RCUK | Engineering and Physical Sciences Research Council (EPSRC)
ID : EP/X019225/1
Organisme : RCUK | Engineering and Physical Sciences Research Council (EPSRC)
ID : EP/W006502/1
Organisme : Royal Society
ID : IES\R3\203066
Organisme : Royal Society
ID : URF\R1\180127
Organisme : Royal Society
ID : RF\ERE\210016
Organisme : Leverhulme Trust
ID : PLP-2021-262
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 852674 - AngstroCAP
Informations de copyright
© 2023. Springer Nature Limited.
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