Gamma-band harmonic responses for beta-band auditory steady-state response are intact in patients with early stage schizophrenia.
ASSR
gamma oscillation
harmonic response
schizophrenia
ultra-high-risk
Journal
Neuropsychopharmacology reports
ISSN: 2574-173X
Titre abrégé: Neuropsychopharmacol Rep
Pays: United States
ID NLM: 101719700
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
revised:
14
09
2023
received:
11
07
2023
accepted:
05
10
2023
medline:
28
11
2023
pubmed:
28
11
2023
entrez:
28
11
2023
Statut:
aheadofprint
Résumé
Gamma oscillations, thought to arise from the activity of ɣ-aminobutyric acid (GABA)ergic interneurons, have potential as a biomarker for schizophrenia. Gamma-band auditory steady-state responses (ASSRs) are notably reduced in both chronic and early-stage schizophrenia patients. Furthermore, alterations in gamma-band ASSRs have been demonstrated in animal models through translational research. However, the 40-Hz harmonic responses of the 20-Hz ASSR are not as well-characterized, despite the possibility that these harmonic oscillatory responses may reflect resonant activity in neural circuits. In this study, we investigated the 40-Hz harmonic response to the 20-Hz ASSR in the early stages of schizophrenia. The study recruited 49 participants, including 15 individuals at ultra-high-risk (UHR) for psychosis, 13 patients with first-episode schizophrenia (FES), and 21 healthy controls (HCs). The 40-Hz harmonic responses of the 20-Hz ASSR were evident in all groups. Interestingly, while previous report observed reduced 40-Hz ASSRs, the 40-Hz harmonic responses of the 20-Hz ASSR were not reduced in the UHR or FES groups. These findings suggest that the gamma-band ASSR and its harmonic responses may represent distinct aspects of pathophysiology in the early stages of schizophrenia.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : JSPS KAKENHI
ID : JP23H02834
Organisme : JSPS KAKENHI
ID : JP21H05174
Organisme : JSPS KAKENHI
ID : JP21H05171
Organisme : JSPS KAKENHI
ID : 22K07573
Organisme : JSPS KAKENHI
ID : 18K07588
Organisme : JSPS KAKENHI
ID : 21H05176
Organisme : JSPS KAKENHI
ID : 22K15744
Organisme : JSPS KAKENHI
ID : 19K17105
Organisme : AMED
ID : JP18dm0307004
Organisme : AMED
ID : JP18dm0307001
Organisme : AMED
ID : JP20dm0207069
Organisme : AMED
ID : JP19dm0207069
Organisme : Moonshot R&D
ID : JPMJMS2021
Organisme : WPI-IRCN at UTIAS
Informations de copyright
© 2023 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
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