GCN2 mediates access to stored amino acids for somatic maintenance during
Drosophila
GCN2
amino acid deprivation
longevity
somatic maintenance
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
14 Nov 2023
14 Nov 2023
Historique:
pubmed:
28
11
2023
medline:
28
11
2023
entrez:
28
11
2023
Statut:
epublish
Résumé
Many mechanistic theories of ageing argue that a progressive failure of somatic maintenance, the use of energy and resources to prevent and repair damage to the cell, underpins ageing. To sustain somatic maintenance an organism must acquire dozens of essential nutrients from the diet, including essential amino acids (EAAs), which are physiologically limiting for many animals. In
Identifiants
pubmed: 38014136
doi: 10.1101/2023.11.14.566972
pmc: PMC10680771
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG007530
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest Statement The authors declare that they have no actual or apparent conflict of interest between authorship of this study and any other activities.
Références
PLoS Biol. 2005 Jul;3(7):e223
pubmed: 16000018
Proc R Soc Lond B Biol Sci. 1979 Sep 21;205(1161):531-46
pubmed: 42059
Mech Ageing Dev. 2005 Mar;126(3):381-7
pubmed: 15664624
J Cell Biol. 2017 Jan 2;216(1):115-129
pubmed: 27979906
Biochem Biophys Res Commun. 2009 Feb 6;379(2):451-5
pubmed: 19114033
PLoS Biol. 2020 Mar 20;18(3):e3000681
pubmed: 32196485
FASEB J. 2000 Nov;14(14):2135-7
pubmed: 11024000
Gene. 1997 Jun 19;192(2):245-50
pubmed: 9224897
Science. 2009 Jul 10;325(5937):201-4
pubmed: 19590001
Cell. 2005 Feb 25;120(4):461-72
pubmed: 15734679
J Gerontol. 1956 Jul;11(3):298-300
pubmed: 13332224
Q Rev Biol. 1981 Sep;56(3):279-303
pubmed: 7031747
Transl Med Aging. 2021;5:17-30
pubmed: 34263088
Genes Dev. 2003 Aug 1;17(15):1882-93
pubmed: 12869585
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
J Cell Biol. 2000 Sep 18;150(6):1507-13
pubmed: 10995454
Mech Ageing Dev. 1977 Nov-Dec;6(6):413-29
pubmed: 926867
Nature. 1977 Nov 24;270(5635):301-4
pubmed: 593350
Nature. 2001 Dec 13;414(6865):799-806
pubmed: 11742412
J Biol Chem. 2009 May 1;284(18):12297-305
pubmed: 19258318
Nutrition. 1989 May-Jun;5(3):155-71; discussion 172
pubmed: 2520283
Elife. 2021 Jan 26;10:
pubmed: 33494859
Trends Cell Biol. 2008 May;18(5):228-35
pubmed: 18346894
Front Aging. 2022 Jun 21;3:944466
pubmed: 35821827
Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73
pubmed: 34518687
J Biol Chem. 2020 May 8;295(19):6518-6531
pubmed: 32241914
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Int J Biochem Cell Biol. 2006;38(9):1476-81
pubmed: 16647875
Cell Metab. 2017 Mar 7;25(3):610-621
pubmed: 28273481
Mol Biol Cell. 2009 Apr;20(7):2004-14
pubmed: 19225150
EMBO J. 2002 Nov 15;21(22):6162-73
pubmed: 12426388
Mol Cell. 2003 Mar;11(3):619-33
pubmed: 12667446
Cell. 2011 Nov 11;147(4):728-41
pubmed: 22078875
Proc Biol Sci. 1996 Jun 22;263(1371):755-9
pubmed: 8763795
J Nutr. 2020 May 1;150(5):1022-1030
pubmed: 31875479
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11269-74
pubmed: 15277680
J Proteome Res. 2011 Apr 1;10(4):1794-805
pubmed: 21254760
Mol Cell. 2000 Nov;6(5):1099-108
pubmed: 11106749
Cell. 1992 Feb 7;68(3):585-96
pubmed: 1739968
J Cell Sci. 2013 Mar 15;126(Pt 6):1406-15
pubmed: 23418347
J Vis Exp. 2013 Jan 07;(71):
pubmed: 23328955
Bioessays. 1989 Apr;10(4):125-7
pubmed: 2730632
Biochem J. 2013 Jan 1;449(1):1-10
pubmed: 23216249
Science. 2004 Jul 16;305(5682):361
pubmed: 15192154
Genetics. 2022 Apr 4;220(4):
pubmed: 35266522
Cell Death Dis. 2019 Feb 8;10(2):111
pubmed: 30737370
Biochem Genet. 1980 Aug;18(7-8):781-91
pubmed: 6781472
J Am Geriatr Soc. 1968 Apr;16(4):408-27
pubmed: 4868749
Nat Protoc. 2016 Dec;11(12):2301-2319
pubmed: 27809316
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4579-83
pubmed: 2660141
Dev Cell. 2004 Aug;7(2):167-78
pubmed: 15296714
Nature. 2009 Dec 24;462(7276):1061-4
pubmed: 19956092
Mol Biol Cell. 2009 Apr;20(7):1992-2003
pubmed: 19225151
Cell Metab. 2014 Mar 4;19(3):418-30
pubmed: 24606899
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Annu Rev Entomol. 1991;36:205-28
pubmed: 2006868
J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1071-81
pubmed: 17921418
Nat Methods. 2016 Sep;13(9):731-40
pubmed: 27348712
Cell Metab. 2011 Aug 3;14(2):154-60
pubmed: 21803286
Nat Metab. 2022 Jul;4(7):944-959
pubmed: 35879463
J Nutr. 1986 Apr;116(4):641-54
pubmed: 3958810
Ageing Res Rev. 2017 Oct;39:78-86
pubmed: 28274839
Cell. 2008 Mar 21;132(6):1025-38
pubmed: 18358814
Genetics. 1998 Jul;149(3):1495-509
pubmed: 9649537
Mol Biol Cell. 2009 Apr;20(7):1981-91
pubmed: 19211835
Evolution. 2000 Jun;54(3):740-50
pubmed: 10937249
Nat Methods. 2014 Jan;11(1):100-5
pubmed: 24240321