The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
GBA
Parkinson’s disease
alpha-synuclein
cathepsin B
iPSC
lysosome
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
pubmed:
28
11
2023
medline:
28
11
2023
entrez:
28
11
2023
Statut:
epublish
Résumé
Variants in the
Identifiants
pubmed: 38014143
doi: 10.1101/2023.11.11.566693
pmc: PMC10680785
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NINDS NIH HHS
ID : K02 NS080915
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AG000935
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA NS003154
Pays : United States
Références
PLoS One. 2013;8(1):e55375
pubmed: 23383169
Brain. 2019 Jan 1;143(1):234-248
pubmed: 31755958
Chem Biol. 2000 Jan;7(1):27-38
pubmed: 10662686
Elife. 2016 Sep 23;5:
pubmed: 27661255
Nucleic Acids Res. 2019 Jan 8;47(D1):D886-D894
pubmed: 30371827
J Neurosci. 2004 Feb 25;24(8):1888-96
pubmed: 14985429
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Nat Rev Neurosci. 2021 Feb;22(2):111-131
pubmed: 33432241
Methods. 2017 Feb 15;115:80-90
pubmed: 27713081
Cell Rep. 2022 Jul 19;40(3):111102
pubmed: 35858558
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4971-4982
pubmed: 32075919
Bioinformatics. 2016 May 15;32(10):1493-501
pubmed: 26773131
Mol Neurodegener. 2023 May 2;18(1):29
pubmed: 37131250
Neurobiol Dis. 2015 Jan;73:244-53
pubmed: 25466281
J Mol Biol. 2023 Jun 15;435(12):168023
pubmed: 36828270
J Neurochem. 2017 Feb;140(4):662-678
pubmed: 27424880
J Exp Med. 2016 Sep 19;213(10):2081-97
pubmed: 27551156
Cell Death Dis. 2023 Apr 8;14(4):255
pubmed: 37031185
Am J Hum Genet. 2013 Jul 11;93(1):42-53
pubmed: 23768515
Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71
pubmed: 15451225
Ann Neurol. 2018 Jul;84(1):117-129
pubmed: 30146727
Ageing Res Rev. 2016 Dec;32:22-37
pubmed: 27125852
Transl Neurodegener. 2023 Jun 13;12(1):31
pubmed: 37312133
Biochemistry. 2022 Feb 15;61(4):228-238
pubmed: 35119840
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Brain Commun. 2021 Sep 25;3(4):fcab223
pubmed: 34632384
Methods. 2022 Jul;203:465-477
pubmed: 34314827
Cell. 2022 Jun 23;185(13):2292-2308.e20
pubmed: 35750034
Lancet Neurol. 2019 Dec;18(12):1091-1102
pubmed: 31701892
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2303789120
pubmed: 37487100
PLoS Genet. 2014 May 15;10(5):e1004383
pubmed: 24830394
Anal Chem. 2014 Jul 15;86(14):7150-8
pubmed: 24927332
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1931-6
pubmed: 26839413
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9322-7
pubmed: 26170293
Eur J Neurosci. 2019 Feb;49(4):510-524
pubmed: 30472757
Autophagy. 2016 Dec;12(12):2504-2505
pubmed: 27786577
Nat Methods. 2020 Nov;17(11):1093-1096
pubmed: 33020655
J Biol Chem. 2019 Jun 21;294(25):9973-9984
pubmed: 31092553
Biostatistics. 2012 Sep;13(4):762-75
pubmed: 22699862
Nucleic Acids Res. 2023 Jan 6;51(D1):D638-D646
pubmed: 36370105
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Mov Disord. 2015 Oct;30(12):1591-601
pubmed: 26474316
J Biol Chem. 2017 Aug 11;292(32):13482-13497
pubmed: 28611062
Methods Protoc. 2021 Jul 19;4(3):
pubmed: 34287353
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
pubmed: 1564476
Front Neurosci. 2020 May 15;14:442
pubmed: 32499675
Mov Disord. 2021 Aug;36(8):1795-1804
pubmed: 33960523
Bone. 2018 Aug;113:41-48
pubmed: 29763751
Mol Pharmacol. 2021 Dec;100(6):526-539
pubmed: 34503973
Hum Mol Genet. 2015 Nov 1;24(21):6013-28
pubmed: 26251043
Parkinsonism Relat Disord. 2020 Apr;73:60-71
pubmed: 31761667
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2389-2394
pubmed: 28193887
J Immunol. 2015 Aug 15;195(4):1685-97
pubmed: 26195813
eNeuro. 2019 Mar 7;6(1):
pubmed: 30863790
J Biol Chem. 2010 Apr 30;285(18):13621-9
pubmed: 20200163
J Biol Chem. 2020 Dec 18;295(51):17497-17513
pubmed: 33453994
J Biol Chem. 2008 Aug 29;283(35):23542-56
pubmed: 18566453
BMC Bioinformatics. 2014 May 02;15:125
pubmed: 24884706
Brain. 2023 Oct 06;:
pubmed: 37804111
Stem Cells Transl Med. 2020 Jun;9(6):697-712
pubmed: 32154672
Neurobiol Aging. 2020 Sep;93:143.e1-143.e4
pubmed: 32371106
Nat Methods. 2022 Jul;19(7):829-832
pubmed: 35654950
Brain. 2021 Mar 3;144(2):462-472
pubmed: 33349842
Hum Mol Genet. 2022 Jul 21;31(14):2424-2437
pubmed: 35181782