Successful addition of topical antibiotic treatment after surgery in treatment-refractory nontuberculous mycobacterial skin and soft tissue infections.

nontuberculous mycobacteria skin and soft tissue infections topical antibiotic treatment

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
14 Dec 2023
Historique:
pubmed: 28 11 2023
medline: 28 11 2023
entrez: 28 11 2023
Statut: ppublish

Résumé

Treatment of skin and soft tissue infections with nontuberculous mycobacteria sometimes fails despite repeated debridements and long-term systemic antibiotic therapy. These treatment-refractory infections can cause significant morbidity and pose a treatment challenge. Following surgery, we treated three patients with negative pressure wound therapy with the instillation and dwell time of topical antibiotics, in addition to systemic antibiotic treatment. Treatment was successful and well tolerated, except for some local irritation.

Identifiants

pubmed: 38014946
doi: 10.1128/aac.00788-23
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0078823

Commentaires et corrections

Type : CommentIn

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Ralf Stemkens (R)

Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Maarten Cobussen (M)

Department of Internal Medicine and Infectious Diseases, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Erik de Laat (E)

Department of Plastic Surgery, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Wouter Hoefsloot (W)

Department of Pulmonary Diseases, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Reinout van Crevel (R)

Department of Internal Medicine and Infectious Diseases, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Rob E Aarnoutse (RE)

Department of Pharmacy, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.

Jakko van Ingen (J)

Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.

Classifications MeSH