Angucyclinones rescue PhLOPS

Cfr adjuvants angucyclinones antibiotic resistance methyltransferase natural anti-microbial products

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
28 Nov 2023
Historique:
medline: 28 11 2023
pubmed: 28 11 2023
entrez: 28 11 2023
Statut: aheadofprint

Résumé

Cfr is an antibiotic resistance enzyme that inhibits five clinically important antibiotic classes, is genetically mobile, and has a minimal fitness cost, making Cfr a serious threat to antibiotic efficacy. The significance of our work is in discovering molecules that inhibit Cfr-dependent methylation of the ribosome, thus protecting the efficacy of the PhLOPS

Identifiants

DOI: 10.1128/mbio.01791-23 PMID: 38014974
pubmed: 38014974
doi: 10.1128/mbio.01791-23
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0179123

Auteurs

Adam J Schaenzer (AJ)

Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Annia Rodriguez Hernandez (A)

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA.

Kaitlyn Tsai (K)

Chemistry and Chemical Biology Graduate Program, University of California San Francisco, San Francisco, California, USA.

Christian Hobson (C)

Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Danica Galonić Fujimori (DG)

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA.
Quantitative Biosciences Institute, University of California San Francisco, San Francisco, California, USA.
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.

Gerard D Wright (GD)

Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
ORCID: 0000-0002-9129-7131

Classifications MeSH