Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode.
Biosensor
Cyclic voltammetry
L-Dopa
Nanoholes array
Surface plasmon resonance
Journal
Discover nano
ISSN: 2731-9229
Titre abrégé: Discov Nano
Pays: Switzerland
ID NLM: 9918540788706676
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
received:
31
08
2023
accepted:
23
11
2023
medline:
28
11
2023
pubmed:
28
11
2023
entrez:
28
11
2023
Statut:
epublish
Résumé
The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte, a nanohole sensing plate is embedded in the EC electrode to enhance the oxidation signal and generate SPR. Cyclic voltammetry (CV) measurement was first conducted to understand the baseline of EC response of L-Dopa. Then, the redox reactions were simultaneously monitored through SPR measurements during the CV voltage scan. The results showed that the limit of detection using traditional CV reached 1.47 μM while using EC-SPR, the limit of detection improved to 1.23 μM. Most importantly, we found a strong correlation between CV current profiles and the SPR reflection spectra. Our results facilitate detecting electrochemical reactions using an optical probing method.
Identifiants
pubmed: 38015329
doi: 10.1186/s11671-023-03930-5
pii: 10.1186/s11671-023-03930-5
pmc: PMC10684436
doi:
Types de publication
Journal Article
Langues
eng
Pagination
145Subventions
Organisme : National Science and Technology Council
ID : 111-2221-E-002 -188 -MY3
Organisme : National Science and Technology Council
ID : 111-2221-E-002 -188 -MY3
Organisme : National Science and Technology Council
ID : 111-2221-E-002 -188 -MY3
Organisme : National Science and Technology Council
ID : 111-2221-E-002 -188 -MY3
Informations de copyright
© 2023. The Author(s).
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