TScan-II: A genome-scale platform for the de novo identification of CD4

CD4+ T cell HIV Pancreatic cancer Sjögren’s disease T cell epitope T cell screening antigen discovery antigen library epitope discovery epitope mutagenesis

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
07 Dec 2023
Historique:
received: 10 04 2023
revised: 12 07 2023
accepted: 25 10 2023
pubmed: 29 11 2023
medline: 29 11 2023
entrez: 28 11 2023
Statut: ppublish

Résumé

CD4

Identifiants

DOI: 10.1016/j.cell.2023.10.024 PMID: 38016469
pubmed: 38016469
pii: S0092-8674(23)01175-3
doi: 10.1016/j.cell.2023.10.024
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5569-5586.e21

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of interests M.H.D., T.K., and S.J.E. are patent holders of the TScan-I and TScan-II technologies. T.K. is a co-founder of TScan Therapeutics and ImmuneID and serves on the Scientific Advisory Board of TScan Therapeutics. S.J.E. is a founder of TScan Therapeutics, ImmuneID, MAZE Therapeutics, and Mirimus. S.J.E. serves on the Scientific Advisory Board of TScan Therapeutics and Maze Therapeutics. In accordance with Partners HealthCare's conflict of interest policies, the Partners Office for Interactions with Industry has reviewed S.J.E.’s financial interest in TScan and determined that it creates no significant risk to the welfare of the participants in this study or to the integrity of the research.

Auteurs

Mohammad H Dezfulian (MH)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Tomasz Kula (T)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Thomas Pranzatelli (T)

Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Nolan Kamitaki (N)

Department of Genetics, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

Qingda Meng (Q)

Department of Medicine, Harvard Medical School, Boston, MA, USA.

Bhuwan Khatri (B)

Genes and Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Paola Perez (P)

Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Qikai Xu (Q)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Aiquan Chang (A)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Ayano C Kohlgruber (AC)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Yumei Leng (Y)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

Ananth Aditya Jupudi (AA)

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Departmentment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Michelle L Joachims (ML)

Genes and Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

John A Chiorini (JA)

Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Christopher J Lessard (CJ)

Genes and Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

A Darise Farris (A)

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Departmentment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Senthil K Muthuswamy (SK)

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Blake M Warner (BM)

Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Stephen J Elledge (SJ)

Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA. Electronic address: selledge@genetics.med.harvard.edu.

Classifications MeSH