CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.

Animals Mice Ceramides / metabolism Diet, High-Fat / adverse effects Glucose / metabolism Homeostasis Hypothalamus / metabolism Mice, Obese Neurons / metabolism Obesity / metabolism Pro-Opiomelanocortin / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
29 Nov 2023
Historique:
received: 06 08 2021
accepted: 17 10 2023
medline: 30 11 2023
pubmed: 29 11 2023
entrez: 28 11 2023
Statut: epublish

Résumé

Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure. Here, we find increased expression of the C

Identifiants

DOI: 10.1038/s41467-023-42595-7 PMID: 38016943 PMC: PMC10684560
pubmed: 38016943
doi: 10.1038/s41467-023-42595-7
pii: 10.1038/s41467-023-42595-7
pmc: PMC10684560
doi:

Substances chimiques

Ceramides 0
Glucose IY9XDZ35W2
Pro-Opiomelanocortin 66796-54-1
CERS6 protein, mouse EC 2.3.1.24

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7824

Subventions

Organisme : NIA NIH HHS
ID : R01 AG067329
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126447
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Philipp Hammerschmidt (P)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Sophie M Steculorum (SM)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Max Planck Institute for Metabolism Research, Research Group Neurocircuit Wiring and Function, Cologne, Germany.
National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
ORCID: 0000-0002-5665-2732

Cécile L Bandet (CL)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Almudena Del Río-Martín (A)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
ORCID: 0009-0005-4414-3358

Lukas Steuernagel (L)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
ORCID: 0000-0003-0043-1436

Vivien Kohlhaas (V)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Marvin Feldmann (M)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.

Luis Varela (L)

Yale Center for Molecular and Systems Metabolism, Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar St., BML 330, New Haven, CT, 06520, USA.
Laboratory of Glia-Neuron Interactions in the Control of Hunger. Achucarro Basque Center for Neuroscience, Leioa, 48940, Spain.
Ikerbasque-Basque Foundation for Science, Bilbao, 48013, Spain.

Adam Majcher (A)

Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
Institute of Clinical Chemistry, University Hospital, Zürich, Switzerland.

Marta Quatorze Correia (M)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.

Rhena F U Klar (RFU)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.

Corinna A Bauder (CA)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Ecem Kaya (E)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Marta Porniece (M)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
ORCID: 0000-0003-2330-5846

Nasim Biglari (N)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Anna Sieben (A)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
ORCID: 0000-0002-3208-6393

Tamas L Horvath (TL)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Yale Center for Molecular and Systems Metabolism, Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar St., BML 330, New Haven, CT, 06520, USA.
Laboratory of Glia-Neuron Interactions in the Control of Hunger. Achucarro Basque Center for Neuroscience, Leioa, 48940, Spain.
Ikerbasque-Basque Foundation for Science, Bilbao, 48013, Spain.
ORCID: 0000-0002-7522-4602

Thorsten Hornemann (T)

Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
Institute of Clinical Chemistry, University Hospital, Zürich, Switzerland.
ORCID: 0000-0002-4218-1087

Susanne Brodesser (S)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
ORCID: 0000-0001-5631-0663

Jens C Brüning (JC)

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany. bruening@sf.mpg.de.
Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany. bruening@sf.mpg.de.
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. bruening@sf.mpg.de.
National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany. bruening@sf.mpg.de.
ORCID: 0000-0002-6619-0092

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Glycosphingolipides › Glycosphingolipides neutres › Céramides › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris obèse › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Cellules › Neurones › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › CerS6-dependent ceramide synthesis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Pro-opiomélanocortine › CerS6-dependent ceramide synthesis in...