Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
received:
19
11
2022
accepted:
06
11
2023
medline:
30
11
2023
pubmed:
29
11
2023
entrez:
28
11
2023
Statut:
epublish
Résumé
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 control samples. Our analysis reveals the prognostic or diagnostic value of dysregulated proteins and phosphorylation sites in important pathways. Moreover, protein co-expression network not only provides comprehensive view of biological features of each histological subtype, but also indicates potential prognostic biomarkers and progression landmarks. Notably, EOC have strong inter-tumor heterogeneity, with significantly different clinical characteristics, proteomic patterns and signaling pathway disorders in CCC, EC, and SC. Finally, we infer MPP7 protein as potential therapeutic target for SC, whose biological functions are confirmed in SC cells. Our proteomic cohort provides valuable resources for understanding molecular mechanisms and developing treatment strategies of distinct histological subtypes.
Identifiants
pubmed: 38016970
doi: 10.1038/s41467-023-43282-3
pii: 10.1038/s41467-023-43282-3
pmc: PMC10684593
doi:
Substances chimiques
Biomarkers, Tumor
0
MPP7 protein, human
0
Membrane Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7802Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82103914
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82073647
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82373674
Informations de copyright
© 2023. The Author(s).
Références
Nucleic Acids Res. 2021 Jan 8;49(D1):D1144-D1151
pubmed: 33237278
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Lancet. 2020 Oct 17;396(10258):1285-1306
pubmed: 32679112
Nat Commun. 2018 Sep 25;9(1):3917
pubmed: 30254278
World J Transl Med. 2014 Apr 12;3(1):1-8
pubmed: 25525571
Cell. 2021 Apr 1;184(7):1661-1670
pubmed: 33798439
Nucleic Acids Res. 2014 Mar;42(5):3228-45
pubmed: 24371270
Nature. 2003 Mar 13;422(6928):226-32
pubmed: 12634796
Blood. 1989 Aug 1;74(2):722-8
pubmed: 2752144
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188584
pubmed: 34157315
Cell Res. 2008 May;18(5):538-48
pubmed: 18427574
Cell Syst. 2018 Mar 28;6(3):271-281.e7
pubmed: 29596782
Nat Rev Cancer. 2009 Mar;9(3):153-66
pubmed: 19238148
Genomics Proteomics Bioinformatics. 2023 Feb;21(1):190-202
pubmed: 35680096
Hum Pathol. 2004 Aug;35(8):907-9
pubmed: 15297958
Innovation (Camb). 2021 Jul 01;2(3):100141
pubmed: 34557778
Nat Rev Genet. 2013 Jan;14(1):35-48
pubmed: 23207911
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Trends Cell Biol. 2018 Nov;28(11):911-925
pubmed: 30061045
N Engl J Med. 2003 Jan 16;348(3):203-13
pubmed: 12529460
Cell Stem Cell. 2011 Nov 4;9(5):402-11
pubmed: 22056138
N Engl J Med. 2016 Nov 3;375(18):1738-1748
pubmed: 27717303
Cancer Cell. 2021 Apr 12;39(4):509-528.e20
pubmed: 33577785
J Clin Oncol. 2017 Nov 10;35(32):3638-3646
pubmed: 28968163
Nature. 2011 Jun 29;474(7353):609-15
pubmed: 21720365
Cancers (Basel). 2020 May 20;12(5):
pubmed: 32443784
Gynecol Oncol. 2014 May;133(2):147-54
pubmed: 24556058
Nat Immunol. 2011 Jun 05;12(7):624-30
pubmed: 21642987
CA Cancer J Clin. 2018 Jan;68(1):7-30
pubmed: 29313949
Nature. 2019 Mar;567(7747):257-261
pubmed: 30814741
Nucleic Acids Res. 2022 Jan 7;50(D1):D687-D692
pubmed: 34788843
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Nat Rev Dis Primers. 2016 Aug 25;2:16061
pubmed: 27558151
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
CA Cancer J Clin. 2018 Jul;68(4):284-296
pubmed: 29809280
Hepatology. 2017 Jul;66(1):152-166
pubmed: 28295457
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
PLoS Biol. 2012;10(12):e1001450
pubmed: 23271954
Gynecol Oncol. 2015 Mar;136(3):491-7
pubmed: 25455734
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Cell. 2016 Jul 28;166(3):755-765
pubmed: 27372738
Cancers (Basel). 2022 Jul 12;14(14):
pubmed: 35884451
Clin Cancer Res. 2018 Oct 15;24(20):5037-5047
pubmed: 30084834
Cancer Res. 2019 Apr 15;79(8):1884-1898
pubmed: 30765601
Nucleic Acids Res. 2021 Jan 8;49(D1):D613-D621
pubmed: 33211851
Hematol Oncol Clin North Am. 2003 Aug;17(4):909-25, vii
pubmed: 12959182
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Nat Rev Genet. 2012 Mar 13;13(4):227-32
pubmed: 22411467
Bioinformatics. 2010 Apr 1;26(7):976-8
pubmed: 20179076
Int J Cancer. 2022 Nov 15;151(10):1717-1725
pubmed: 35751416
Nucleic Acids Res. 2021 Jan 8;49(D1):D325-D334
pubmed: 33290552
Cell Syst. 2015 Dec 23;1(6):417-425
pubmed: 26771021
Nucleic Acids Res. 2021 Jan 8;49(D1):D545-D551
pubmed: 33125081
BMC Bioinformatics. 2011 Mar 17;12:77
pubmed: 21414208
Geburtshilfe Frauenheilkd. 2021 Oct;81(10):1145-1153
pubmed: 34629493
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Cancer Discov. 2011 Jul;1(2):144-57
pubmed: 22303516
CA Cancer J Clin. 2019 Jul;69(4):280-304
pubmed: 31099893
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Expert Opin Drug Discov. 2015;10(9):991-1010
pubmed: 26087073
Nat Rev Cancer. 2014 Sep;14(9):598-610
pubmed: 25098269
N Engl J Med. 2016 Nov 17;375(20):1925-1936
pubmed: 27959613
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
Cell. 2020 Jul 9;182(1):226-244.e17
pubmed: 32649875
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Front Cell Dev Biol. 2020 Apr 03;8:222
pubmed: 32309283
Nucleic Acids Res. 2018 Jun 1;46(10):5269-5285
pubmed: 29554348
Oncol Rep. 2015 Feb;33(2):685-92
pubmed: 25483274
Int J Cancer. 2022 Nov 1;151(9):1535-1541
pubmed: 35322413
Cell. 2018 Sep 20;175(1):159-170.e16
pubmed: 30241606
Nucleic Acids Res. 2022 Jan 7;50(D1):D543-D552
pubmed: 34723319
J Extracell Vesicles. 2012 Apr 16;1:
pubmed: 24009883
Obstet Gynecol. 2015 Sep;126(3):491-497
pubmed: 26244529
Adv Cancer Res. 2020;146:1-21
pubmed: 32241384
Science. 2011 Mar 25;331(6024):1559-64
pubmed: 21436443
Nature. 2013 Feb 7;494(7435):60-4
pubmed: 23334420
Nat Rev Cancer. 2022 May;22(5):298-313
pubmed: 35236940
Clin Cancer Res. 2022 Jun 1;28(11):2278-2285
pubmed: 35131903
Nat Rev Immunol. 2013 Jan;13(1):46-57
pubmed: 23237964
Cell Rep Med. 2020 Apr 21;1(1):
pubmed: 32529193
Theranostics. 2020 Jun 1;10(16):7178-7192
pubmed: 32641986
Gynecol Oncol. 2018 Apr;149(1):43-48
pubmed: 29605049
Int J Gynaecol Obstet. 2000 Aug;70(2):209-62
pubmed: 11041682
Semin Cancer Biol. 2020 May;62:192-200
pubmed: 31518697