Platelet-to-lymphocyte ratio and serum hsCRP levels in third trimester and adverse pregnancy outcomes in women with gestational diabetes mellitus.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
received:
18
07
2023
accepted:
25
11
2023
medline:
30
11
2023
pubmed:
29
11
2023
entrez:
28
11
2023
Statut:
epublish
Résumé
Gestational diabetes mellitus (GDM) is a major complication of pregnancy. GDM is associated with a higher risk of adverse pregnancy outcomes (APO). The purpose of this study was to assess the association between third-trimester platelet to lymphocyte ratio (PLR) and high-sensitivity C-reactive protein (hsCRP) concentration and the risk of APO in GDM pregnant women. This study selected 406 non-elderly gestational diabetes patients diagnosed in the Renmin Hospital of Wuhan University from May 2021 to February 2023 as the research objects. According to the presence or absence of APO, they were divided into an APO group (n = 171) and a non-APO group (n = 235). Logistic regression model to evaluate the correlation between PLR and hsCRP and APO in women with GDM; Restricted cubic spline analyses was used to explore nonlinear correlations between PLR or hsCRP and the risk of APO; ROC curve analysis of the diagnostic performance of PLR and hsCRP for APO in women with GDM. APO occurred in 171 of the 406 included participants. Compared with the non-APO group, patients in the APO group had higher PLR and hsCRP levels. The incidence of APO was positively associated with PLR and the hsCRP level in each logistic regression model (P < 0.05). After adjusting for all the risk factors included in this study, restricted cubic spline analyses found that the PLR and the hsCRP level were positively associated with the risk of APO. The levels of PLR and hsCRP in the third trimester are related to the occurrence of APO in women with GDM, and high levels of PLR and hsCRP may indicate the occurrence of APO.
Identifiants
pubmed: 38017249
doi: 10.1038/s41598-023-48371-3
pii: 10.1038/s41598-023-48371-3
pmc: PMC10684644
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20963Subventions
Organisme : National Natural Science Foundation of China
ID : 81772265
Informations de copyright
© 2023. The Author(s).
Références
Int J Environ Res Public Health. 2020 Dec 18;17(24):
pubmed: 33353136
BMJ. 2022 May 25;377:e067946
pubmed: 35613728
Diabetes Res Clin Pract. 2021 Jun;176:108868
pubmed: 34023341
J Matern Fetal Neonatal Med. 2017 Sep;30(17):2086-2091
pubmed: 27678153
Kardiol Pol. 2017;75(7):666-673
pubmed: 28394006
Am J Perinatol. 2016 Dec;33(14):1337-1356
pubmed: 27159203
Chin Med J (Engl). 2019 Jan 20;132(2):154-160
pubmed: 30614859
J Matern Fetal Neonatal Med. 2014 Jul;27(11):1108-12
pubmed: 24090161
J Obstet Gynaecol Res. 2023 Jul;49(7):1723-1728
pubmed: 37088799
Clin Lab. 2021 Feb 1;67(2):
pubmed: 33616345
Curr Pharm Des. 2021;27(2):263-275
pubmed: 32679014
Obstet Gynecol Sci. 2020 Mar;63(2):133-140
pubmed: 32206652
Nat Rev Endocrinol. 2012 Nov;8(11):639-49
pubmed: 22751341
Obstet Gynecol Clin North Am. 2017 Jun;44(2):207-217
pubmed: 28499531
Platelets. 2021 Apr 3;32(3):293-294
pubmed: 33600267
Biomed Res Int. 2016;2016:9060143
pubmed: 27403440
Curr Diab Rep. 2018 Jul 23;18(9):68
pubmed: 30039471
Circ Res. 2018 Jan 19;122(2):337-351
pubmed: 29348254
Front Endocrinol (Lausanne). 2021 Nov 03;12:723650
pubmed: 34803906
Am J Obstet Gynecol. 2011 Aug;205(2):132.e1-12
pubmed: 21575931
Diabetologia. 2016 Jul;59(7):1396-1399
pubmed: 27174368
J Clin Lab Anal. 2021 Apr;35(4):e23719
pubmed: 33507619
Metabolism. 2020 Mar;104:154142
pubmed: 31930973
Diabetes Care. 2010 Mar;33(3):676-82
pubmed: 20190296
Clin Chim Acta. 2021 Dec;523:87-96
pubmed: 34508686
Nat Rev Cardiol. 2019 Mar;16(3):166-179
pubmed: 30429532
Semin Arthritis Rheum. 2021 Feb;51(1):219-229
pubmed: 33385862
Trends Endocrinol Metab. 2018 Nov;29(11):743-754
pubmed: 30297319
J Immunol Res. 2023 Feb 13;2023:6841344
pubmed: 36814523
Curr Diab Rep. 2016 Jan;16(1):7
pubmed: 26742932
Front Immunol. 2018 Apr 13;9:754
pubmed: 29706967
Brain Behav Immun. 2018 May;70:61-75
pubmed: 29499302
Int J Mol Sci. 2021 Sep 19;22(18):
pubmed: 34576285
J Biol Regul Homeost Agents. 2021 May 20;35(3):889-900
pubmed: 34013686
Taiwan J Obstet Gynecol. 2015 Apr;54(2):160-6
pubmed: 25951721
Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2192-2197
pubmed: 31412738
Diabetologia. 2021 May;64(5):1169-1183
pubmed: 33544171
J Clin Endocrinol Metab. 2021 Nov 19;106(12):e5075-e5087
pubmed: 34272865
BMJ. 2020 May 13;369:m1361
pubmed: 32404325
Eur J Endocrinol. 2016 Feb;174(2):R43-51
pubmed: 26431552
Endocrinol Metab Clin North Am. 2019 Sep;48(3):479-493
pubmed: 31345518
Taiwan J Obstet Gynecol. 2021 Mar;60(2):221-224
pubmed: 33678319
J Obstet Gynaecol. 2020 Apr;40(3):349-353
pubmed: 31498010
Clin Chim Acta. 2018 Aug;483:48-56
pubmed: 29678631
Eur J Haematol. 2014;92(5):367-76
pubmed: 24400878
Front Immunol. 2019 Jul 26;10:1731
pubmed: 31402914
Clin Chem. 2013 Sep;59(9):1310-21
pubmed: 23536513
Diabetes Res Clin Pract. 2011 Dec;94(3):426-33
pubmed: 21917349
Ann Lab Med. 2019 Jul;39(4):345-357
pubmed: 30809980
Obstet Gynecol. 2018 Feb;131(2):e49-e64
pubmed: 29370047