Breaking barriers: exploring mechanisms behind opening the blood-brain barrier.
BBB stimulation
Blood–Brain barrier
Focused ultrasound
Neurological therapeutics
Tight junctions
Journal
Fluids and barriers of the CNS
ISSN: 2045-8118
Titre abrégé: Fluids Barriers CNS
Pays: England
ID NLM: 101553157
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
received:
15
09
2023
accepted:
13
11
2023
medline:
30
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
The blood-brain barrier (BBB) is a selectively permeable membrane that separates the bloodstream from the brain. While useful for protecting neural tissue from harmful substances, brain-related diseases are difficult to treat due to this barrier, as it also limits the efficacy of drug delivery. To address this, promising new approaches for enhancing drug delivery are based on disrupting the BBB using physical means, including optical/photothermal therapy, electrical stimulation, and acoustic/mechanical stimulation. These physical mechanisms can temporarily and locally open the BBB, allowing drugs and other substances to enter. Focused ultrasound is particularly promising, with the ability to focus energies to targeted, deep-brain regions. In this review, we examine recent advances in physical approaches for temporary BBB disruption, describing their underlying mechanisms as well as evaluating the utility of these physical approaches with regard to their potential risks and limitations. While these methods have demonstrated efficacy in disrupting the BBB, their safety, comparative efficacy, and practicality for clinical use remain an ongoing topic of research.
Identifiants
pubmed: 38017530
doi: 10.1186/s12987-023-00489-2
pii: 10.1186/s12987-023-00489-2
pmc: PMC10683235
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
87Subventions
Organisme : National Health and Medical Research Council
ID : ID2003446
Informations de copyright
© 2023. The Author(s).
Références
Vascul Pharmacol. 2002 Jun;38(6):323-37
pubmed: 12529927
J Cereb Blood Flow Metab. 2015 May;35(5):747-50
pubmed: 25757748
J Biomed Opt. 2013 Jul;18(7):075002
pubmed: 23839531
Cells. 2018 Mar 23;7(4):
pubmed: 29570659
Sci Rep. 2018 Jun 18;8(1):9265
pubmed: 29915178
Neurobiol Dis. 2010 Jan;37(1):13-25
pubmed: 19664713
J Pharmacol Exp Ther. 2019 Feb;368(2):179-186
pubmed: 30530622
Neurosurg Focus. 2015 Mar;38(3):E10
pubmed: 25727219
World Neurosurg. 2018 Apr;112:166-177
pubmed: 29410102
Biomed Opt Express. 2017 Oct 17;8(11):5040-5048
pubmed: 29188101
J Am Acad Dermatol. 2015 Jun;72(6):1078-80
pubmed: 25981004
Mol Pharmacol. 2005 Mar;67(3):749-56
pubmed: 15602007
FEBS Lett. 2006 Jul 24;580(17):4252-60
pubmed: 16828752
J Membr Biol. 1998 Oct 1;165(3):201-11
pubmed: 9767674
Ther Deliv. 2010 Dec;1(6):775-84
pubmed: 22834013
Cell Commun Signal. 2013 May 28;11(1):37
pubmed: 23714586
J Ther Ultrasound. 2014 Oct 16;2:17
pubmed: 25671132
Oper Neurosurg (Hagerstown). 2020 Jul 1;19(1):9-18
pubmed: 31853548
Biomaterials. 2012 Jan;33(2):704-12
pubmed: 22019122
Cell Mol Life Sci. 2019 May;76(10):1987-2002
pubmed: 30734065
Circ Res. 2007 Feb 2;100(2):158-73
pubmed: 17272818
Exp Neurol. 2013 Oct;248:16-29
pubmed: 23707300
Exp Cell Res. 2017 Sep 1;358(1):39-44
pubmed: 28372972
Neurooncol Adv. 2020 Jun 30;2(1):vdaa071
pubmed: 32666049
RSC Adv. 2017;7(68):42811-42818
pubmed: 29308191
Biochim Biophys Acta. 2016 May;1862(5):887-900
pubmed: 26705676
Brain Res. 2005 Oct 5;1058(1-2):62-72
pubmed: 16181616
Nat Commun. 2016 Mar 22;7:11100
pubmed: 27000523
J Cell Biol. 2015 May 25;209(4):493-506
pubmed: 26008742
IEEE Trans Biomed Eng. 2010 Jan;57(1):145-54
pubmed: 19846365
J Neurol. 2013 Nov;260(11):2701-14
pubmed: 23287972
Nature. 2010 Nov 25;468(7323):557-61
pubmed: 20944627
FEBS Lett. 2011 Feb 18;585(4):606-12
pubmed: 21276448
J Biomed Opt. 2013 Sep;18(9):098001
pubmed: 24002195
Biomed Opt Express. 2018 Sep 14;9(10):4850-4862
pubmed: 30319907
Cells. 2022 May 01;11(9):
pubmed: 35563826
Photochem Photobiol Sci. 2009 Oct;8(10):1401-7
pubmed: 19789809
Cell. 2015 Nov 19;163(5):1064-1078
pubmed: 26590417
PLoS One. 2019 Sep 4;14(9):e0222113
pubmed: 31483843
Cancer Res. 1992 Jun 15;52(12):3443-8
pubmed: 1534512
PLoS One. 2013;8(3):e58995
pubmed: 23527068
Alzheimers Dement. 2009 Sep;5(5):427-32
pubmed: 19751922
Adv Drug Deliv Rev. 2005 Apr 25;57(6):883-917
pubmed: 15820558
Pharmaceutics. 2015 Aug 03;7(3):175-87
pubmed: 26247958
Cytokine. 2011 Jul;55(1):110-5
pubmed: 21524919
Cell Mol Neurobiol. 2000 Apr;20(2):131-47
pubmed: 10696506
Nat Commun. 2019 Sep 26;10(1):4373
pubmed: 31558719
BMC Neurol. 2010 Nov 15;10:114
pubmed: 21078165
J Cereb Blood Flow Metab. 2017 Jan;37(1):4-24
pubmed: 27837191
Pharm Res. 2022 Mar;39(3):427-439
pubmed: 35257286
Semin Perinatol. 2004 Oct;28(5):326-33
pubmed: 15686263
PLoS One. 2016 Feb 24;11(2):e0148613
pubmed: 26910903
J Cereb Blood Flow Metab. 2010 Jul;30(7):1394-402
pubmed: 20332798
Drug Deliv. 2019 Dec;26(1):551-565
pubmed: 31928355
J Pharmacol Exp Ther. 2017 Nov;363(2):275-283
pubmed: 28819070
Pharmaceutics. 2021 Jan 27;13(2):
pubmed: 33513968
J Biol Chem. 2002 Mar 22;277(12):10445-51
pubmed: 11784713
Bioelectrochemistry. 2014 Oct;99:30-9
pubmed: 24976141
Ultrasonics. 2022 Aug;124:106742
pubmed: 35381523
J Inherit Metab Dis. 2013 May;36(3):437-49
pubmed: 23609350
Neuroscience. 2016 May 26;323:170-82
pubmed: 25595973
Neurochem Int. 2021 Mar;144:104952
pubmed: 33400964
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Invest Ophthalmol Vis Sci. 1983 Nov;24(11):1519-24
pubmed: 6642931
J Neurosurg. 2016 Jun;124(6):1602-10
pubmed: 26566207
Int Rev Psychiatry. 2017 Apr;29(2):168-177
pubmed: 28430535
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Adv Drug Deliv Rev. 2014 Jun;72:94-109
pubmed: 24462453
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412
pubmed: 25561720
Biomedicines. 2022 Jun 11;10(6):
pubmed: 35740406
Acta Neurol Scand. 1970;46(1):85-92
pubmed: 4983875
Neurobiol Dis. 2004 Jun;16(1):1-13
pubmed: 15207256
Adv Drug Deliv Rev. 2022 Jun;185:114311
pubmed: 35489652
Dev Cell. 2011 Aug 16;21(2):193-215
pubmed: 21839917
Front Neurosci. 2016 Mar 31;10:134
pubmed: 27065792
Nat Cell Biol. 2008 Aug;10(8):923-34
pubmed: 18604199
J Cell Physiol. 2011 Nov;226(11):3053-63
pubmed: 21302304
Cancer Imaging. 2019 Oct 15;19(1):65
pubmed: 31615562
Biomolecules. 2022 Sep 22;12(10):
pubmed: 36291557
Chem Rec. 2017 Aug;17(8):775-802
pubmed: 28042681
J Cereb Blood Flow Metab. 2013 Oct;33(10):1500-13
pubmed: 23921899
J Cereb Blood Flow Metab. 2014 Jul;34(7):1197-204
pubmed: 24780905
Fluids Barriers CNS. 2011 Jan 18;8(1):3
pubmed: 21349151
Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183298
pubmed: 32353377
Ann Biomed Eng. 2023 Apr 28;:
pubmed: 37115366
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
Magn Reson Med. 2011 Sep;66(3):821-30
pubmed: 21465543
Ultrasound Med Biol. 2004 Jul;30(7):979-89
pubmed: 15313330
PLoS One. 2014 Dec 09;9(12):e114311
pubmed: 25490097
Clin Anat. 2018 Sep;31(6):812-823
pubmed: 29637627
Eur J Neurosci. 2015 Aug;42(3):1933-40
pubmed: 25989209
Acta Neurobiol Exp (Wars). 2011;71(4):393-408
pubmed: 22237490
NeuroRx. 2005 Jan;2(1):3-14
pubmed: 15717053
Clin Cancer Res. 2019 Jul 1;25(13):3793-3801
pubmed: 30890548
Curr Neuropharmacol. 2021;19(2):114-126
pubmed: 32348225
Neurol Res. 2004 Dec;26(8):846-53
pubmed: 15727268
Amino Acids. 1998;14(1-3):95-103
pubmed: 9871448
Nat Commun. 2018 Jul 25;9(1):2336
pubmed: 30046032
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7780-5
pubmed: 12032360
Adv Sci (Weinh). 2021 Aug;8(16):e2101090
pubmed: 34085418
Magn Reson Med. 2012 Mar;67(3):769-77
pubmed: 21858862
Nat Rev Mol Cell Biol. 2010 Jul;11(7):502-14
pubmed: 20571587
Front Vet Sci. 2022 Oct 18;9:1039745
pubmed: 36330152
Cancers (Basel). 2019 Nov 23;11(12):
pubmed: 31771214
J Neurosurg. 2017 Apr;126(4):1351-1361
pubmed: 27285538
Neuro Oncol. 2016 Jan;18(1):27-36
pubmed: 26359209
Clin Neurophysiol. 2009 Jun;120(6):1161-7
pubmed: 19403329
Semin Cell Dev Biol. 2015 Feb;38:2-6
pubmed: 25681530
Ann Biomed Eng. 2020 Apr;48(4):1256-1270
pubmed: 31916126
ISRN Biochem. 2013 May 21;2013:238428
pubmed: 25937958
Brain Stimul. 2012 Jul;5(3):175-195
pubmed: 22037126
Int J Pharm. 2017 Oct 5;531(1):372-388
pubmed: 28755993
Acta Neurochir (Wien). 2005 Jan;147(1):57-65; discussion 65
pubmed: 15565479
Biomed Mater. 2020 Dec 17;16(1):015006
pubmed: 33331293
J Cell Sci. 2012 Apr 15;125(Pt 8):1855-64
pubmed: 22544950
Bioelectromagnetics. 2013 Jan;34(1):22-30
pubmed: 22674251
Oper Neurosurg (Hagerstown). 2020 Nov 16;19(6):741-749
pubmed: 32735671
Front Chem. 2021 Jun 10;9:691697
pubmed: 34178948
Stereotact Funct Neurosurg. 2021;99(4):329-342
pubmed: 33302282
J Cereb Blood Flow Metab. 2017 May;37(5):1670-1686
pubmed: 27356551
J Control Release. 2015 Aug 28;212:1-9
pubmed: 26071631
Neurochem Res. 2007 Dec;32(12):2032-45
pubmed: 17457674
Fluids Barriers CNS. 2012 Nov 09;9(1):23
pubmed: 23140302
J Appl Physiol (1985). 1999 Jul;87(1):261-8
pubmed: 10409584
Pharmaceutics. 2022 Oct 19;14(10):
pubmed: 36297666
Mov Disord. 2019 Sep;34(9):1243-1251
pubmed: 31291491
CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81
pubmed: 21617154
Nat Med. 2013 Dec;19(12):1584-96
pubmed: 24309662
Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):374-83
pubmed: 16970981
Ultrasound Med Biol. 2008 Jul;34(7):1093-104
pubmed: 18378064
Mol Biol Cell. 2010 Feb 15;21(4):584-96
pubmed: 20032304
Nature. 2005 Sep 15;437(7057):426-31
pubmed: 16163360
PLoS One. 2012;7(11):e50482
pubmed: 23226293
Nature. 2010 Nov 25;468(7323):562-6
pubmed: 20944625
Science. 2011 Dec 23;334(6063):1727-31
pubmed: 22144466
J Cell Biol. 2003 May 12;161(3):653-60
pubmed: 12743111
IEEE J Sel Top Quantum Electron. 2021 Jul-Aug;27(4):
pubmed: 33519171
Biochim Biophys Acta. 2011 Feb;1812(2):252-64
pubmed: 20619340
Front Cell Dev Biol. 2021 Sep 28;9:731028
pubmed: 34650977
Fluids Barriers CNS. 2023 Sep 22;20(1):67
pubmed: 37737197
Lasers Surg Med. 2003;33(2):75-80
pubmed: 12913878
J Control Release. 2016 Aug 10;235:34-47
pubmed: 27208862
Lasers Surg Med. 2008 Oct;40(8):535-42
pubmed: 18798293
Cancer Treat Rev. 2004 Aug;30(5):415-23
pubmed: 15245774
PLoS One. 2012;7(8):e42817
pubmed: 22900052
Drug Deliv. 2019 Dec;26(1):459-469
pubmed: 30957567
J Cell Sci. 2004 Jan 1;117(Pt 1):19-29
pubmed: 14657270
Radiol Oncol. 2016 Feb 16;50(1):28-38
pubmed: 27069447
Sci Rep. 2019 Jan 23;9(1):321
pubmed: 30674905
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a002899
pubmed: 20457565