Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines.
Delivery
Nanocarrier
Nanodrug
Nanotechnology
Traditional Chinese Medicines
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
29 Nov 2023
29 Nov 2023
Historique:
received:
01
09
2023
accepted:
16
10
2023
medline:
30
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their poor water solubility, low bioavailability, and potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations. This review summarizes the recent advances in nanocarrier-based delivery systems for various types of active constituents of TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, and quinones, from different natural sources. This review covers the design and preparation of nanocarriers, their characterization, and in vitro/vivo evaluations. Additionally, this review highlights the challenges and opportunities in the field and suggests future directions for research. Nanocarrier-based delivery systems have shown great potential in improving the therapeutic efficacy of TCMs, and this review may serve as a comprehensive resource to researchers in this field.
Identifiants
pubmed: 38017573
doi: 10.1186/s12951-023-02165-x
pii: 10.1186/s12951-023-02165-x
pmc: PMC10685519
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
456Subventions
Organisme : National Natural Science Foundation of China
ID : 82204322
Organisme : National Natural Science Foundation of China
ID : 82104480
Organisme : Central Public Welfare Research Institutes
ID : ZZ14-YQ-055
Organisme : Central Public Welfare Research Institutes
ID : ZZ14-YQ-050
Organisme : Central Public Welfare Research Institutes
ID : ZZ14-YQ-059
Organisme : the Young Elite Scientists Sponsorship Program by CACM
ID : 2021QNRC2B29
Informations de copyright
© 2023. The Author(s).
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