[Multigenerational epigenetic inheritance in human: the past, present and perspectives].
L’héritage épigénétique multigénérationnel chez l’Homme : le passé, le présent et les perspectives.
DNA methylation
environmental factors
epigenetics
facteurs environnementaux
héritage transgénérationnel
méthylation de l’ADN
transgenerational inheritance
épigénétique
Journal
Biologie aujourd'hui
ISSN: 2105-0686
Titre abrégé: Biol Aujourdhui
Pays: France
ID NLM: 101544020
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
05
2023
medline:
30
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
ppublish
Résumé
Nowadays, a growing body of evidence suggests that the developmental programs of each individual could be modified. The acquired new phenotypic changes could be persistent throughout the individual's life and even transmitted to the next generation. While the exact mechanism for that preservation is not well understood yet, there are many evidences showing that epigenetic alterations, which are robust and dynamic in response to the influence of the environmental factors, could be responsible for that inheritance. A growing number of external factors such as social stress, environmental pollution and climate changes make adaptation to these environmental changes rather challenging. According to the Developmental Origin of Human Disease theory, formulated by David Barker, environmental conditions experienced during the first phases of development can have long term effects on later phases of life. This phenomenon is linked to the biological plasticity of development, which allows reprogramming of physiological functions in response to different stimuli. Consequently, in utero exposure to environmental pollutants can increase predisposition to different pathologies that can occur both in early and later phases of life not only in the living generation but also in subsequent ones. Here, we have summarised some findings in human epigenetic research studies performed for the past few years which address the question whether transgenerational effects observed in model organisms could also occur in humans. L’héritage épigénétique multigénérationnel chez l’Homme : le passé, le présent et les perspectives. De nos jours, de nombreuses études suggèrent que les programmes de développement de chaque individu seraient susceptibles d’être modifiés. Les changements phénotypiques acquis pourraient persister tout au long de la vie de l’individu et même être transmis à la génération suivante. Bien que le mécanisme exact de cette préservation ne soit pas encore bien compris, de nombreuses observations suggèrent que les altérations épigénétiques en réponse à l’influence des facteurs environnementaux seraient responsables de cette hérédité. Le nombre croissant de facteurs externes tels que le stress social, la pollution environnementale et les changements climatiques rend difficile l’adaptation à ce nouvel environnement. Selon la théorie de l’origine développementale des maladies humaines, formulée par David Barker, les conditions environnementales rencontrées au cours des premières phases du développement peuvent avoir des effets à long terme sur les phases ultérieures de la vie. Ce phénomène est lié à la plasticité biologique du développement, qui permet une reprogrammation des fonctions physiologiques en réponse à différents stimuli. L’exposition in utero à des polluants environnementaux accroîtrait la prédisposition à des pathologies survenant dans les phases précoces et tardives de la vie, non seulement pour les générations présentes mais aussi les suivantes. Nous avons résumé ici des résultats d’études épidémiologiques et épigénétiques menées ces dernières années sur des données humaines afin de savoir si les effets transgénérationnels observés dans des organismes modèles peuvent également exister chez l’homme.
Autres résumés
Type: Publisher
(fre)
L’héritage épigénétique multigénérationnel chez l’Homme : le passé, le présent et les perspectives.
Identifiants
pubmed: 38018951
doi: 10.1051/jbio/2023032
pii: jbio230032
doi:
Types de publication
English Abstract
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
233-243Informations de copyright
© Société de Biologie, 2023.
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