Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells.
gaze stabilization
hair cells
inner ear
mouse
multisensory integration
neuroscience
ototoxicity
vestibulo-ocular reflex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 Nov 2023
29 Nov 2023
Historique:
medline:
30
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
The functional complementarity of the vestibulo-ocular reflex (VOR) and optokinetic reflex (OKR) allows for optimal combined gaze stabilization responses (CGR) in light. While sensory substitution has been reported following complete vestibular loss, the capacity of the central vestibular system to compensate for partial peripheral vestibular loss remains to be determined. Here, we first demonstrate the efficacy of a 6-week subchronic ototoxic protocol in inducing transient and partial vestibular loss which equally affects the canal- and otolith-dependent VORs. Immunostaining of hair cells in the vestibular sensory epithelia revealed that organ-specific alteration of type I, but not type II, hair cells correlates with functional impairments. The decrease in VOR performance is paralleled with an increase in the gain of the OKR occurring in a specific range of frequencies where VOR normally dominates gaze stabilization, compatible with a sensory substitution process. Comparison of unimodal OKR or VOR versus bimodal CGR revealed that visuo-vestibular interactions remain reduced despite a significant recovery in the VOR. Modeling and sweep-based analysis revealed that the differential capacity to optimally combine OKR and VOR correlates with the reproducibility of the VOR responses. Overall, these results shed light on the multisensory reweighting occurring in pathologies with fluctuating peripheral vestibular malfunction.
Identifiants
pubmed: 38019267
doi: 10.7554/eLife.88819
pii: 88819
pmc: PMC10686621
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-20-CE37-0016
Organisme : Agence Nationale de la Recherche
ID : ERANET NEURON ANR-20-NEUR-0005
Organisme : Agencia Estatal de Investigación
ID : ERANET NEURON PCI2020-120681-2
Organisme : Centre National d'Etudes Spatiales
ID : DAR CNES 4500072566
Informations de copyright
© 2023, Schenberg et al.
Déclaration de conflit d'intérêts
LS, AP, FS, TB, CB, DF, MT, JL, MB No competing interests declared
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