Serum zinc deficiency is a potential risk factor for the occurrence of levodopa-induced dyskinesia in drug-naïve Parkinson's disease.

Parkinson’s disease heavy metal levodopa-induced dyskinesia risk factors zinc

Journal

Frontiers in aging neuroscience

ISSN: 1663-4365

Titre abrégé: Front Aging Neurosci

Pays: Switzerland

ID NLM: 101525824

Informations de publication

Date de publication:
2023

Historique:

received: 24 08 2023

accepted: 23 10 2023

medline: 29 11 2023

pubmed: 29 11 2023

entrez: 29 11 2023

Statut: epublish

Résumé

Since environmental factors, especially heavy metals, were highlighted in the pathogenesis of Parkinson's disease (PD), there are many epidemiologic studies regarding heavy metals and PD risk. However, longitudinal studies regarding the impacts of heavy metals on motor and nonmotor symptoms of PD are scarce. In the current study, we compared the serum levels of five heavy metals, such as zinc(Zn), copper(Cu), lead(Pb), mercury(Hg), and manganese(Mn), in 111 previously drug-naïve PD patients ( Zn deficiency was significantly higher in the PD with LID group than in the PD without LID group (79.58 ± 12.28 versus 88.16 ± 15.15 μg/L). Lower serum Zn levels were significantly correlated with age of onset, levodopa equivalent daily dose (LEDD) at 3 months, and Korean version of the Mini-Mental State Examination (K-MMSE) scores ( This study suggests that serum Zn deficiency might be a risk factor for LID in drug-naïve PD patients.

Sections du résumé

Background UNASSIGNED

Methods UNASSIGNED

In the current study, we compared the serum levels of five heavy metals, such as zinc(Zn), copper(Cu), lead(Pb), mercury(Hg), and manganese(Mn), in 111 previously drug-naïve PD patients (

Results UNASSIGNED

Zn deficiency was significantly higher in the PD with LID group than in the PD without LID group (79.58 ± 12.28 versus 88.16 ± 15.15 μg/L). Lower serum Zn levels were significantly correlated with age of onset, levodopa equivalent daily dose (LEDD) at 3 months, and Korean version of the Mini-Mental State Examination (K-MMSE) scores (

Conclusion UNASSIGNED

This study suggests that serum Zn deficiency might be a risk factor for LID in drug-naïve PD patients.

Identifiants

DOI: 10.3389/fnagi.2023.1282367 PMID: 38020782 PMC: PMC10652755

pubmed: 38020782

doi: 10.3389/fnagi.2023.1282367

pmc: PMC10652755

doi:

Types de publication

Journal Article

Langues

eng

Pagination

1282367

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

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